The identification of metal-protein complexes by gel chromatography and neutron activation analysis

A method for the identification of protein-metal complexes in biological fluids by a combination of gel chromatography and neutron activation analysis is proposed. The distribution of protein-bound copper in human serum is studied as an example of the method. On propose une méthode d'identifica...

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Bibliographic Details
Published in:Analytica chimica acta 1969, Vol.44 (1), p.1-7
Main Authors: Evans, D.J.R., Fritze, K.
Format: Article
Language:English
Subjects:
Activation Analysis
Animals
Blood Proteins
Chromatography
Metals
Methods
Protein Binding
Rats
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Summary:A method for the identification of protein-metal complexes in biological fluids by a combination of gel chromatography and neutron activation analysis is proposed. The distribution of protein-bound copper in human serum is studied as an example of the method. On propose une méthode d'identification de complexes métal-protéines dans les liquides biologiques, par chromatographie sur gel et activation neutronique. Le partage du cuivre-protéine dans le sérum humain est choisi comme exemple. Es wird eine Methode zur Identifizierung von Protein-Metall-Komplexen in biologischen Flüssigkeiten vorgeschlagen, bei der die Gel-Chromatographie mit der Neutronenaktivierungsanalyse kombiniert wird. Als ein Beispiel dieser Methode wird die Verteilung von proteingebundenem Kupfer im menschlichen Serum untersucht.
ISSN:0003-2670
1873-4324
DOI:10.1016/S0003-2670(01)81729-3