Klinefelter's Syndrome, Dizygotic Twinning and Diabetes Mellitus

Engel and Forbes 1,2 noted that chromosomal non-disjunction commonly occurs in families with a genetic predisposition to “autoimmunity”. From a review of the literature, and a study of eighteen patients with chromatin-positive Klinefelter's syndrome, Nielsen 3 proposed that this syndrome is pro...

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Bibliographic Details
Published in:Nature (London) 1969-01, Vol.221 (5176), p.175-177
Main Author: BURCH, P. R. J
Format: Article
Language:English
Subjects:
Autoimmune Diseases
California
Denmark
Diabetes Mellitus - epidemiology
Diseases in Twins - epidemiology
England
Female
Finland
Genetics, Population
Humanities and Social Sciences
Humans
Klinefelter Syndrome - epidemiology
letter
Male
Maternal Age
multidisciplinary
Pregnancy
Pregnancy, Multiple
Probability
Science
Science (multidisciplinary)
Turner Syndrome - immunology
Wales
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Summary:Engel and Forbes 1,2 noted that chromosomal non-disjunction commonly occurs in families with a genetic predisposition to “autoimmunity”. From a review of the literature, and a study of eighteen patients with chromatin-positive Klinefelter's syndrome, Nielsen 3 proposed that this syndrome is probably associated with dizygotic twinning. He also summarized the results of three surveys which indicate that the frequency of twin births in sibships containing Turner's syndrome is about twice that in the general population. He concluded 3 that similar mechanisms may be responsible for sex chromosome non-disjunction and dizygotic twinning.
ISSN:0028-0836
1476-4687
DOI:10.1038/221175a0