Breed differences in the proportional morbidity of testicular tumours and distribution of histopathologic types in a population-based canine cancer registry

Histologically verified tumours submitted to the Norwegian Canine Cancer Register from 1990 to 1998 were studied (n = 14 401). The proportion of testicular tumours (n = 345) was 2.4%, and the breakdown of histological tumour diagnoses is presented. The frequency of the most common histopathological...

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Bibliographic Details
Published in:Veterinary & comparative oncology 2011-03, Vol.9 (1), p.45-54
Main Authors: Nødtvedt, A, Gamlem, H, Gunnes, G, Grotmol, T, Indrebø, A, Moe, L
Format: Article
Language:English
Subjects:
Age Factors
Animals
cancer register
dog
Dog Diseases - diagnosis
Dog Diseases - epidemiology
Dog Diseases - pathology
Dogs
epidemiology
histopathology
Leydig Cell Tumor - diagnosis
Leydig Cell Tumor - epidemiology
Leydig Cell Tumor - pathology
Leydig Cell Tumor - veterinary
Male
Norway - epidemiology
Pedigree
proportional morbidity ratio
Registries
Seminoma - diagnosis
Seminoma - epidemiology
Seminoma - pathology
Seminoma - veterinary
Sertoli Cell Tumor - diagnosis
Sertoli Cell Tumor - epidemiology
Sertoli Cell Tumor - pathology
Sertoli Cell Tumor - veterinary
Species Specificity
testis tumour
validation
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Summary:Histologically verified tumours submitted to the Norwegian Canine Cancer Register from 1990 to 1998 were studied (n = 14 401). The proportion of testicular tumours (n = 345) was 2.4%, and the breakdown of histological tumour diagnoses is presented. The frequency of the most common histopathological types was 33% interstitial (Leydig), 26.4% Sertoli and 33.9% seminomas/germ cell tumours. The average age at diagnosis was 10 years, but was significantly lower for Sertoli cell tumours (8.6 years) than for the other tumour types. Following a histopathological re-evaluation, 22.5% of the original tumor diagnoses were modified. Proportional morbidity ratios were calculated and individuals from the breeds Shetland sheepdog and Collie were five times more likely to have testicular tumours than the overall average for the registry. Breed differences in the distribution of histopathologic types were observed. Shetland sheepdog and Collie were most commonly diagnosed with Sertoli cell tumours, while all tumours from Norwegian elkhound in this material were seminomas.
ISSN:1476-5810
1476-5829
DOI:10.1111/j.1476-5829.2010.00231.x