Effects of Pro-Hyp, a Collagen Hydrolysate-Derived Peptide, on Hyaluronic Acid Synthesis Using in Vitro Cultured Synovium Cells and Oral Ingestion of Collagen Hydrolysates in a Guinea Pig Model of Osteoarthritis

Proline-hydroxyproline (Pro-Hyp) stimulated hyaluronic acid production in cultured synovium cells. It was detected in guinea pig blood after oral ingestion of collagen hydrolysates. Oral administration of collagen hydrolysates increased the amount of proteoglycans in the epiphyses. It also reduced t...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2010, Vol.74 (10), p.2096-2099
Main Authors: OHARA, Hiroki, IIDA, Hiroyuki, ITO, Kyoko, TAKEUCHI, Yasuo, NOMURA, Yoshihiro
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cells, Cultured
Collagen - metabolism
collagen hydrolysates
Dipeptides - administration & dosage
Dipeptides - metabolism
Dipeptides - pharmacology
Dipeptides - therapeutic use
Disease Models, Animal
Dose-Response Relationship, Drug
Eating
Fundamental and applied biological sciences. Psychology
Guinea Pigs
hyaluronic acid
Hyaluronic Acid - biosynthesis
Hydrolysis
Male
osteoarthritis
Osteoarthritis - drug therapy
Osteoarthritis - metabolism
proline-hydroxyproline (Pro-Hyp)
proteoglycan
Synovial Membrane - cytology
Synovial Membrane - drug effects
Synovial Membrane - metabolism
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Summary:Proline-hydroxyproline (Pro-Hyp) stimulated hyaluronic acid production in cultured synovium cells. It was detected in guinea pig blood after oral ingestion of collagen hydrolysates. Oral administration of collagen hydrolysates increased the amount of proteoglycans in the epiphyses. It also reduced the morphological changes associated with osteoarthritic cartilage destruction of the knee joint. The results suggest that collagen hydrolysates have therapeutic potential for treatment of osteoarthritis.
ISSN:0916-8451
1347-6947
1347-6947
DOI:10.1271/bbb.100193