Loading…

Long-term Results of High-dose-rate Brachytherapy and External-beam Radiotherapy in the Primary Treatment of Endometrial Cancer

In this report we update our long-term follow-up results of the prospective study whose aim was to evaluate the efficacy of high-dose-rate (HDR) brachytherapy in combination with external-beam radiotherapy (EBRT) in the treatment of medically inoperable endometrial cancer. Between 1995 and 1998, 29...

Full description

Saved in:

Bibliographic Details
Published in:	JOURNAL OF RADIATION RESEARCH 2010, Vol.51 (6), p.675-681
Main Authors:	Inciura, Arturas, Atkocius, Vydmantas, Juozaityte, Elona, Vaitkiene, Daiva
Format:	Article
Language:	English
Subjects:	Aged Aged, 80 and over Brachytherapy Cancer Carcinoma Care and treatment Contraindications Endometrial cancer Endometrial Neoplasms - mortality Endometrial Neoplasms - pathology Endometrial Neoplasms - radiotherapy Endometrium Female Follow-Up Studies Gynecologic Surgical Procedures Health aspects Humans Kaplan-Meier Estimate Lithuania - epidemiology Middle Aged Neoplasm Staging Prospective Studies Radiation Radiotherapy Radiotherapy Dosage Survival
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c759t-edab03b859fbae832a75045fe811846b8e5c6877622004f429a07bb91a6d9b483
cites	cdi_FETCH-LOGICAL-c759t-edab03b859fbae832a75045fe811846b8e5c6877622004f429a07bb91a6d9b483
container_end_page	681
container_issue	6
container_start_page	675
container_title	JOURNAL OF RADIATION RESEARCH
container_volume	51
creator	Inciura, Arturas Atkocius, Vydmantas Juozaityte, Elona Vaitkiene, Daiva
description	In this report we update our long-term follow-up results of the prospective study whose aim was to evaluate the efficacy of high-dose-rate (HDR) brachytherapy in combination with external-beam radiotherapy (EBRT) in the treatment of medically inoperable endometrial cancer. Between 1995 and 1998, 29 patients with stages I-III medically inoperable carcinoma of endometrium were treated with definitive irradiation. All patients underwent combined intracavitary HDR brachytherapy and EBRT. The EBRT dose was 50 Gy with midline shield from 16 Gy. The HDR brachytherapy dose was 50 Gy, delivered in 5 fractions in a weekly schedule. Overall survival (OS) at 5 and 10 years was 48.3% and 20.7%, respectively. Disease-specific survival (DSS) at 5 and 10 years was 73.5% and 67.9%, respectively. The 10-year DSS rate was 73.5% for all stages, 85.7% for Stage I disease, 71.4% for Stage II, and 16.7% for stage III disease. Late Grade 1-2 radiation complications were observed in 4 patients (13.8%). Our long-term follow-up confirms that HDR brachytherapy with EBRT appears to be an effective and safe treatment for stage I and II medically inoperable endometrial cancer.
doi_str_mv	10.1269/jrr.10080
format	article
fullrecord	<record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_851468542</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A536154497</galeid><sourcerecordid>A536154497</sourcerecordid><originalsourceid>FETCH-LOGICAL-c759t-edab03b859fbae832a75045fe811846b8e5c6877622004f429a07bb91a6d9b483</originalsourceid><addsrcrecordid>eNqFkt-L1DAQx4so3nLeg_-AFHxQH7omzY-mj3fLnicsKHI-h7Sd7mZtkzVJwX3yX3fq3nkoogQyQ-bzHWYmk2XPKVnSUtZv9yEsKSGKPMoWlPG6qKmoHmcLwtFnRJKz7CJG2xAqJGKUPs3OSkqpRNEi-77xblskCGP-CeI0pJj7Pr-x213R-QhFMAnyq2Da3THtIJjDMTeuy9ffUOLMUDRgUGk66-_D1uXo5h-DHU045rcBTBrBpTnv2nV-hBSsGfKVcS2EZ9mT3gwRLu7sefb5en27uik2H969X11uirYSdSqgMw1hjRJ13xhQrDSVIFz0gP0oLhsFopWqqmRZEsJ7XtaGVE1TUyO7uuGKnWevTnkPwX-dICY92tjCMBgHfopaCcqlErz8P0mFEJTIGsnX_yQpK5nC8hhB9OUf6N5P8wCR4vhRvMZuHqitGUBb1_uEk5-T6kvBJBVIVkgt_0Lh6WC0rXfQW3z_TfDmJGiDjzFArw-nz9GU6HmHNO6Q_rlDyL64K3RqRuh-kfcbg8D1CcCobc3g3WAdPLTTfpF7HwLokmB2QuZRoak0kZXAS1HOxFzVD3_K1QQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1444949045</pqid></control><display><type>article</type><title>Long-term Results of High-dose-rate Brachytherapy and External-beam Radiotherapy in the Primary Treatment of Endometrial Cancer</title><source>OUP_牛津大学出版社OA刊</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) - Open Access English articles</source><creator>Inciura, Arturas ; Atkocius, Vydmantas ; Juozaityte, Elona ; Vaitkiene, Daiva</creator><creatorcontrib>Inciura, Arturas ; Atkocius, Vydmantas ; Juozaityte, Elona ; Vaitkiene, Daiva ; Kaunas University of Medicine ; Vilnius University ; Institute of Oncology</creatorcontrib><description>In this report we update our long-term follow-up results of the prospective study whose aim was to evaluate the efficacy of high-dose-rate (HDR) brachytherapy in combination with external-beam radiotherapy (EBRT) in the treatment of medically inoperable endometrial cancer. Between 1995 and 1998, 29 patients with stages I-III medically inoperable carcinoma of endometrium were treated with definitive irradiation. All patients underwent combined intracavitary HDR brachytherapy and EBRT. The EBRT dose was 50 Gy with midline shield from 16 Gy. The HDR brachytherapy dose was 50 Gy, delivered in 5 fractions in a weekly schedule. Overall survival (OS) at 5 and 10 years was 48.3% and 20.7%, respectively. Disease-specific survival (DSS) at 5 and 10 years was 73.5% and 67.9%, respectively. The 10-year DSS rate was 73.5% for all stages, 85.7% for Stage I disease, 71.4% for Stage II, and 16.7% for stage III disease. Late Grade 1-2 radiation complications were observed in 4 patients (13.8%). Our long-term follow-up confirms that HDR brachytherapy with EBRT appears to be an effective and safe treatment for stage I and II medically inoperable endometrial cancer.</description><identifier>ISSN: 0449-3060</identifier><identifier>ISSN: 1349-9157</identifier><identifier>EISSN: 1349-9157</identifier><identifier>DOI: 10.1269/jrr.10080</identifier><identifier>PMID: 21116100</identifier><language>eng</language><publisher>England: THE JAPAN RADIATION RESEARCH SOCIETY</publisher><subject>Aged ; Aged, 80 and over ; Brachytherapy ; Cancer ; Carcinoma ; Care and treatment ; Contraindications ; Endometrial cancer ; Endometrial Neoplasms - mortality ; Endometrial Neoplasms - pathology ; Endometrial Neoplasms - radiotherapy ; Endometrium ; Female ; Follow-Up Studies ; Gynecologic Surgical Procedures ; Health aspects ; Humans ; Kaplan-Meier Estimate ; Lithuania - epidemiology ; Middle Aged ; Neoplasm Staging ; Prospective Studies ; Radiation ; Radiotherapy ; Radiotherapy Dosage ; Survival</subject><ispartof>JOURNAL OF RADIATION RESEARCH, 2010, Vol.51 (6), p.675-681</ispartof><rights>COPYRIGHT 2010 Oxford University Press</rights><rights>Copyright Japan Science and Technology Agency 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c759t-edab03b859fbae832a75045fe811846b8e5c6877622004f429a07bb91a6d9b483</citedby><cites>FETCH-LOGICAL-c759t-edab03b859fbae832a75045fe811846b8e5c6877622004f429a07bb91a6d9b483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21116100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inciura, Arturas</creatorcontrib><creatorcontrib>Atkocius, Vydmantas</creatorcontrib><creatorcontrib>Juozaityte, Elona</creatorcontrib><creatorcontrib>Vaitkiene, Daiva</creatorcontrib><creatorcontrib>Kaunas University of Medicine</creatorcontrib><creatorcontrib>Vilnius University</creatorcontrib><creatorcontrib>Institute of Oncology</creatorcontrib><title>Long-term Results of High-dose-rate Brachytherapy and External-beam Radiotherapy in the Primary Treatment of Endometrial Cancer</title><title>JOURNAL OF RADIATION RESEARCH</title><addtitle>J Radiat Res</addtitle><description>In this report we update our long-term follow-up results of the prospective study whose aim was to evaluate the efficacy of high-dose-rate (HDR) brachytherapy in combination with external-beam radiotherapy (EBRT) in the treatment of medically inoperable endometrial cancer. Between 1995 and 1998, 29 patients with stages I-III medically inoperable carcinoma of endometrium were treated with definitive irradiation. All patients underwent combined intracavitary HDR brachytherapy and EBRT. The EBRT dose was 50 Gy with midline shield from 16 Gy. The HDR brachytherapy dose was 50 Gy, delivered in 5 fractions in a weekly schedule. Overall survival (OS) at 5 and 10 years was 48.3% and 20.7%, respectively. Disease-specific survival (DSS) at 5 and 10 years was 73.5% and 67.9%, respectively. The 10-year DSS rate was 73.5% for all stages, 85.7% for Stage I disease, 71.4% for Stage II, and 16.7% for stage III disease. Late Grade 1-2 radiation complications were observed in 4 patients (13.8%). Our long-term follow-up confirms that HDR brachytherapy with EBRT appears to be an effective and safe treatment for stage I and II medically inoperable endometrial cancer.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Brachytherapy</subject><subject>Cancer</subject><subject>Carcinoma</subject><subject>Care and treatment</subject><subject>Contraindications</subject><subject>Endometrial cancer</subject><subject>Endometrial Neoplasms - mortality</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Endometrial Neoplasms - radiotherapy</subject><subject>Endometrium</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gynecologic Surgical Procedures</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Lithuania - epidemiology</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Prospective Studies</subject><subject>Radiation</subject><subject>Radiotherapy</subject><subject>Radiotherapy Dosage</subject><subject>Survival</subject><issn>0449-3060</issn><issn>1349-9157</issn><issn>1349-9157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqFkt-L1DAQx4so3nLeg_-AFHxQH7omzY-mj3fLnicsKHI-h7Sd7mZtkzVJwX3yX3fq3nkoogQyQ-bzHWYmk2XPKVnSUtZv9yEsKSGKPMoWlPG6qKmoHmcLwtFnRJKz7CJG2xAqJGKUPs3OSkqpRNEi-77xblskCGP-CeI0pJj7Pr-x213R-QhFMAnyq2Da3THtIJjDMTeuy9ffUOLMUDRgUGk66-_D1uXo5h-DHU045rcBTBrBpTnv2nV-hBSsGfKVcS2EZ9mT3gwRLu7sefb5en27uik2H969X11uirYSdSqgMw1hjRJ13xhQrDSVIFz0gP0oLhsFopWqqmRZEsJ7XtaGVE1TUyO7uuGKnWevTnkPwX-dICY92tjCMBgHfopaCcqlErz8P0mFEJTIGsnX_yQpK5nC8hhB9OUf6N5P8wCR4vhRvMZuHqitGUBb1_uEk5-T6kvBJBVIVkgt_0Lh6WC0rXfQW3z_TfDmJGiDjzFArw-nz9GU6HmHNO6Q_rlDyL64K3RqRuh-kfcbg8D1CcCobc3g3WAdPLTTfpF7HwLokmB2QuZRoak0kZXAS1HOxFzVD3_K1QQ</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Inciura, Arturas</creator><creator>Atkocius, Vydmantas</creator><creator>Juozaityte, Elona</creator><creator>Vaitkiene, Daiva</creator><general>THE JAPAN RADIATION RESEARCH SOCIETY</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>Long-term Results of High-dose-rate Brachytherapy and External-beam Radiotherapy in the Primary Treatment of Endometrial Cancer</title><author>Inciura, Arturas ; Atkocius, Vydmantas ; Juozaityte, Elona ; Vaitkiene, Daiva</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c759t-edab03b859fbae832a75045fe811846b8e5c6877622004f429a07bb91a6d9b483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Brachytherapy</topic><topic>Cancer</topic><topic>Carcinoma</topic><topic>Care and treatment</topic><topic>Contraindications</topic><topic>Endometrial cancer</topic><topic>Endometrial Neoplasms - mortality</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Endometrial Neoplasms - radiotherapy</topic><topic>Endometrium</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gynecologic Surgical Procedures</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Lithuania - epidemiology</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Prospective Studies</topic><topic>Radiation</topic><topic>Radiotherapy</topic><topic>Radiotherapy Dosage</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inciura, Arturas</creatorcontrib><creatorcontrib>Atkocius, Vydmantas</creatorcontrib><creatorcontrib>Juozaityte, Elona</creatorcontrib><creatorcontrib>Vaitkiene, Daiva</creatorcontrib><creatorcontrib>Kaunas University of Medicine</creatorcontrib><creatorcontrib>Vilnius University</creatorcontrib><creatorcontrib>Institute of Oncology</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>JOURNAL OF RADIATION RESEARCH</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inciura, Arturas</au><au>Atkocius, Vydmantas</au><au>Juozaityte, Elona</au><au>Vaitkiene, Daiva</au><aucorp>Kaunas University of Medicine</aucorp><aucorp>Vilnius University</aucorp><aucorp>Institute of Oncology</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term Results of High-dose-rate Brachytherapy and External-beam Radiotherapy in the Primary Treatment of Endometrial Cancer</atitle><jtitle>JOURNAL OF RADIATION RESEARCH</jtitle><addtitle>J Radiat Res</addtitle><date>2010</date><risdate>2010</risdate><volume>51</volume><issue>6</issue><spage>675</spage><epage>681</epage><pages>675-681</pages><issn>0449-3060</issn><issn>1349-9157</issn><eissn>1349-9157</eissn><abstract>In this report we update our long-term follow-up results of the prospective study whose aim was to evaluate the efficacy of high-dose-rate (HDR) brachytherapy in combination with external-beam radiotherapy (EBRT) in the treatment of medically inoperable endometrial cancer. Between 1995 and 1998, 29 patients with stages I-III medically inoperable carcinoma of endometrium were treated with definitive irradiation. All patients underwent combined intracavitary HDR brachytherapy and EBRT. The EBRT dose was 50 Gy with midline shield from 16 Gy. The HDR brachytherapy dose was 50 Gy, delivered in 5 fractions in a weekly schedule. Overall survival (OS) at 5 and 10 years was 48.3% and 20.7%, respectively. Disease-specific survival (DSS) at 5 and 10 years was 73.5% and 67.9%, respectively. The 10-year DSS rate was 73.5% for all stages, 85.7% for Stage I disease, 71.4% for Stage II, and 16.7% for stage III disease. Late Grade 1-2 radiation complications were observed in 4 patients (13.8%). Our long-term follow-up confirms that HDR brachytherapy with EBRT appears to be an effective and safe treatment for stage I and II medically inoperable endometrial cancer.</abstract><cop>England</cop><pub>THE JAPAN RADIATION RESEARCH SOCIETY</pub><pmid>21116100</pmid><doi>10.1269/jrr.10080</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 0449-3060
ispartof	JOURNAL OF RADIATION RESEARCH, 2010, Vol.51 (6), p.675-681
issn	0449-3060 1349-9157 1349-9157
language	eng
recordid	cdi_proquest_miscellaneous_851468542
source	OUP_牛津大学出版社OA刊; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) - Open Access English articles
subjects	Aged Aged, 80 and over Brachytherapy Cancer Carcinoma Care and treatment Contraindications Endometrial cancer Endometrial Neoplasms - mortality Endometrial Neoplasms - pathology Endometrial Neoplasms - radiotherapy Endometrium Female Follow-Up Studies Gynecologic Surgical Procedures Health aspects Humans Kaplan-Meier Estimate Lithuania - epidemiology Middle Aged Neoplasm Staging Prospective Studies Radiation Radiotherapy Radiotherapy Dosage Survival
title	Long-term Results of High-dose-rate Brachytherapy and External-beam Radiotherapy in the Primary Treatment of Endometrial Cancer
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T08%3A26%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Long-term%20Results%20of%20High-dose-rate%20Brachytherapy%20and%20External-beam%20Radiotherapy%20in%20the%20Primary%20Treatment%20of%20Endometrial%20Cancer&rft.jtitle=JOURNAL%20OF%20RADIATION%20RESEARCH&rft.au=Inciura,%20Arturas&rft.aucorp=Kaunas%20University%20of%20Medicine&rft.date=2010&rft.volume=51&rft.issue=6&rft.spage=675&rft.epage=681&rft.pages=675-681&rft.issn=0449-3060&rft.eissn=1349-9157&rft_id=info:doi/10.1269/jrr.10080&rft_dat=%3Cgale_proqu%3EA536154497%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c759t-edab03b859fbae832a75045fe811846b8e5c6877622004f429a07bb91a6d9b483%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1444949045&rft_id=info:pmid/21116100&rft_galeid=A536154497&rfr_iscdi=true