DNA microarray analysis of the liver of mice treated with cobalt chloride

To investigate the in vivo effects of cobalt chloride on gene expression at early time points, DNA microarray analysis was performed on the liver of mice injected subcutaneously with cobalt chloride. The liver tissue samples were taken 0.5, 1, and 3 hr after injection. Of the 14 genes up-regulated a...

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Bibliographic Details
Published in:Journal of toxicological sciences 2010/12/01, Vol.35(6), pp.935-939
Main Authors: Matsumoto, Kanako, Fujishiro, Hitomi, Satoh, Masahiko, Himeno, Seiichiro
Format: Article
Language:English
Subjects:
Animals
Cobalt
Cobalt - toxicity
DNA microarray
DNA, Complementary - genetics
Gene Expression - drug effects
Gene Expression Profiling
Liver
Liver - drug effects
Liver - metabolism
Liver - pathology
Male
Mice
Mice, Inbred ICR
Mouse
Oligonucleotide Array Sequence Analysis
RNA - genetics
RNA, Complementary - genetics
Toxicity Tests
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Summary:To investigate the in vivo effects of cobalt chloride on gene expression at early time points, DNA microarray analysis was performed on the liver of mice injected subcutaneously with cobalt chloride. The liver tissue samples were taken 0.5, 1, and 3 hr after injection. Of the 14 genes up-regulated at 0.5 hr after injection, 7 are related to immunological responses, and 4 of the 7 were found to be involved in the activation of interferon.
ISSN:0388-1350
1880-3989
1880-3989
DOI:10.2131/jts.35.935