Possible Involvement of Prolactin in the Synthesis of Lactoferrin in Bovine Mammary Epithelial Cells

Bovine mammary epithelial cells (bMECs) synthesize lactoferrin, which is secreted into milk. Our results suggest that prolactin stimulated secretion of lactoferrin in primary bMECs and their clonal cell line under serum-free conditions. Prolactin also stimulated mRNA expression of lactoferrin in the...

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Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2008-04, Vol.72 (4), p.1103-1106
Main Authors: NAKAJIMA, Kei-ichi, NAKAMURA, Masato, GAO, Xiao-Dong, KOZAKAI, Takaharu
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
bovine
Cattle
Cell Line
Clone Cells
Epithelial Cells - metabolism
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - drug effects
Janus Kinases - metabolism
lactoferrin
Lactoferrin - biosynthesis
mammary epithelial cells
Mammary Glands, Animal - cytology
prolactin
Prolactin - pharmacology
RNA, Messenger - genetics
RNA, Messenger - metabolism
Tyrphostins - pharmacology
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Summary:Bovine mammary epithelial cells (bMECs) synthesize lactoferrin, which is secreted into milk. Our results suggest that prolactin stimulated secretion of lactoferrin in primary bMECs and their clonal cell line under serum-free conditions. Prolactin also stimulated mRNA expression of lactoferrin in the clonal cell line. This effect was reduced by AG-490, suggesting that the prolactin-stimulated mRNA expression of lactoferrin was mediated by Janus kinase (JAK)2.
ISSN:0916-8451
1347-6947
1347-6947
DOI:10.1271/bbb.70713