The Stimulatory Activities of Polysaccharide Compounds Derived from Algae Extracts on Insulin Secretion in Vitro

We prepared two series of polysaccharide compounds derived from algae extracts and investigated their stimulatory activity on insulin secretion in vitro using the rat pancreatic cell line, RIN-5F. Several of the compounds exhibited significant stimulatory activity in a dose-dependent manner without...

Full description

Saved in:
Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2008/05/01, Vol.31(5), pp.921-924
Main Authors: Zhang, Dandan, Fujii, Isao, Lin, Changzheng, Ito, Kaori, Guan, Huashi, Zhao, Ji'en, Shinohara, Makoto, Matsukura, Makoto
Format: Article
Language:English
Subjects:
algae-derived extract
Animals
anti-diabetic
Cell Line
Cell Survival - drug effects
Dose-Response Relationship, Drug
Eukaryota - chemistry
Glyburide - pharmacology
Hypoglycemic Agents - pharmacology
Indicators and Reagents
Insulin - metabolism
insulin secretion
Insulin-Secreting Cells - drug effects
Insulin-Secreting Cells - metabolism
Islets of Langerhans - cytology
Islets of Langerhans - drug effects
Islets of Langerhans - metabolism
Lipopolysaccharides - pharmacology
marine organism
polysaccharide
Rats
Stimulation, Chemical
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We prepared two series of polysaccharide compounds derived from algae extracts and investigated their stimulatory activity on insulin secretion in vitro using the rat pancreatic cell line, RIN-5F. Several of the compounds exhibited significant stimulatory activity in a dose-dependent manner without apparent cytotoxicity at concentrations above 10 μM. Glybenclamide, a commonly prescribed sulfonylurea (SU) against diabetes mellitus type II, was used as a positive control and showed moderate cytotoxicity in the cell culture assay system. Amylin (IAPP; islet amyloid polypeptide), an inhibitor for glybenclamide, did not inhibit the activity of the isolated compounds, suggesting that they act through a mechanism(s) different from glybenclamide. Algae-derived extracts could be candidates for a new class of anti-diabetic drugs.
ISSN:0918-6158
1347-5215
1347-5215
DOI:10.1248/bpb.31.921