The Influence of Diabetes on the Relationship between N-terminal Pro-B-type Natriuretic Peptide and Body Mass Index

This study evaluated the influence of diabetes on the relationship between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and body mass index (BMI). Simultaneous NT-proBNP and echocardiographic Doppler examinations were performed in 1117 patients with dyspnoea undergoing cardiac catheterizati...

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Bibliographic Details
Published in:Journal of international medical research 2010-09, Vol.38 (5), p.1737-1748
Main Authors: Kim, BH, Kim, IJ, Cho, KI, Kim, SM, Lee, HG, Kim, TI
Format: Article
Language:English
Subjects:
Aged
Atherosclerosis - physiopathology
Body Composition
Body Mass Index
Cardiac Catheterization
Diabetes Complications - epidemiology
Diabetes Mellitus, Type 2 - physiopathology
Dyspnea - blood
Dyspnea - diagnosis
Dyspnea - etiology
Echocardiography
Echocardiography, Doppler
Female
Humans
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Obesity - physiopathology
Overweight - physiopathology
Peptide Fragments - blood
Protein Precursors - blood
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Summary:This study evaluated the influence of diabetes on the relationship between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and body mass index (BMI). Simultaneous NT-proBNP and echocardiographic Doppler examinations were performed in 1117 patients with dyspnoea undergoing cardiac catheterization. Patients were divided into BMI ≥ 25 kg/m2 (obese), 23 − 25 kg/m2 (overweight) and < 23 kg/m2 (non-obese) groups. In the 803 non-diabetic patients, mean plasma NT-proBNP levels in non-obese, overweight and obese patients showed a significant negative correlation with BMI (862.3 ± 228.8 pg/ml, 611.5 ± 149.7 pg/ml, 278.3 ± 172.5 pg/ml, respectively). In the 314 patients with diabetes, there was no correlation between BMI and NT-proBNP. This study demonstrated that obese patients had reduced concentrations of NT-proBNP compared with non-obese patients, despite having higher left ventricular filling pressures. NT-proBNP was not reduced in obese patients with diabetes. These results suggest that factors other than cardiac status impact on NT-proBNP concentration.
ISSN:0300-0605
1473-2300
DOI:10.1177/147323001003800519