Fast and Flexible Synthesis of Pantothenic Acid and CJ-15,801

The fast and efficient syntheses of pantothenic acid and the antiparasitic agent CJ-15,801 have been achieved starting from a common imide unit through the selective manipulation of enamide intermediates.

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Bibliographic Details
Published in:Organic letters 2011-02, Vol.13 (4), p.800-803
Main Authors: Sewell, Alan L, Villa, Mathew V. J, Matheson, Mhairi, Whittingham, William G, Marquez, Rodolfo
Format: Article
Language:English
Subjects:
Imides - chemistry
Molecular Conformation
Molecular Structure
Pantothenic Acid - analogs & derivatives
Pantothenic Acid - chemical synthesis
Pantothenic Acid - chemistry
Pantothenic Acid - pharmacology
Plasmodium falciparum - drug effects
Stereoisomerism
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Description
Summary:The fast and efficient syntheses of pantothenic acid and the antiparasitic agent CJ-15,801 have been achieved starting from a common imide unit through the selective manipulation of enamide intermediates.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol103114w