Differential expression of the nuclear receptors farnesoid X receptor (FXR) and pregnane X receptor (PXR) for grading dysplasia in patients with Barrett's oesophagus

van de Winkel A, van Zoest K P M, van Dekken H, Moons L M G, Kuipers E J & van der Laan L J W 
(2011) Histopathology58, 246–253
Differential expression of the nuclear receptors farnesoid X receptor (FXR) and pregnane X receptor (PXR) for grading dysplasia in patients with Barrett’s oesophagus Ai...

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Published in:Histopathology 2011-01, Vol.58 (2), p.246-253
Main Authors: van de Winkel, Anouk, van Zoest, Katinka P M, van Dekken, Herman, Moons, Leon M G, Kuipers, Ernst J, van der Laan, Luc J W
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Adult
Aged
Aged, 80 and over
Area Under Curve
Barrett Esophagus - metabolism
Barrett Esophagus - pathology
Barrett's oesophagus
Biological and medical sciences
biomarker
Biomarkers, Tumor - analysis
Disease Progression
dysplasia
Esophagus
farnesoid X receptor
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunohistochemistry
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Metaplasia
Middle Aged
oesophageal adenocarcinoma
Other diseases. Semiology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Precancerous Conditions - metabolism
Precancerous Conditions - pathology
pregnane X receptor
Receptors, Cytoplasmic and Nuclear - biosynthesis
Receptors, Steroid - biosynthesis
ROC Curve
Sensitivity and Specificity
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Summary:van de Winkel A, van Zoest K P M, van Dekken H, Moons L M G, Kuipers E J & van der Laan L J W 
(2011) Histopathology58, 246–253
Differential expression of the nuclear receptors farnesoid X receptor (FXR) and pregnane X receptor (PXR) for grading dysplasia in patients with Barrett’s oesophagus Aims:  To investigate expression of nuclear receptors farnesoid X receptor (FXR) and pregnane X receptor (PXR) as a diagnostic tool to improve grading of dysplasia in Barrett’s oesophagus patients. Methods and results:  Immunostaining was analysed on a total of 192 biopsy samples of 22 Barrett’s patients with no dysplasia (ND), 17 with low‐grade dysplasia (LGD), 20 high‐grade dysplasia (HGD) and 24 with adenocarcinoma (AC). Nuclear FXR expression was observed in 15 of 22 (68%) ND cases versus none of 19 HGD; 3 of 17 (18%); LGD; 5 of 60 (8%) patients with AC (P 
ISSN:0309-0167
1365-2559
DOI:10.1111/j.1365-2559.2011.03743.x