Dealcoholised beers reduce atherosclerosis and expression of adhesion molecules in apoE-deficient mice

Polyphenols exert beneficial effects in atherosclerosis. The crucial step in atherosclerosis is the recruitment of monocytes to the subendothelial space, induced by endothelial adhesion molecules through the activation of factors such as NF-κB. We studied the effect of a dealcoholised lager beer (DL...

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Bibliographic Details
Published in:British journal of nutrition 2011-03, Vol.105 (5), p.721-730
Main Authors: Martinez, Nuria, Urpi-Sarda, Mireia, Martinez-Gonzalez, Miguel Angel, Andres-Lacueva, Cristina, Mitjavila, Maria Teresa
Format: Article
Language:English
Subjects:
adhesion
Animals
Aorta
Apolipoproteins E - deficiency
Apolipoproteins E - genetics
atherosclerosis
Atherosclerosis - drug therapy
Atherosclerosis - metabolism
Atherosclerosis - pathology
Beer
beers
Biological and medical sciences
body weight
cell adhesion
Cell Adhesion Molecules - genetics
Cell Adhesion Molecules - metabolism
Diet
Feeding. Feeding behavior
Flavonoids - pharmacology
Flavonoids - therapeutic use
Fundamental and applied biological sciences. Psychology
gene expression
Intercellular Adhesion Molecule-1 - genetics
Intercellular Adhesion Molecule-1 - metabolism
Male
messenger RNA
Mice
Mice, Inbred C57BL
Mice, Knockout
monocytes
NF-kappa B - metabolism
Nutritional Immunology
P-Selectin - metabolism
Phenols - pharmacology
Phenols - therapeutic use
Phytotherapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Polyphenols
protein synthesis
RNA, Messenger - metabolism
Vascular Cell Adhesion Molecule-1 - genetics
Vascular Cell Adhesion Molecule-1 - metabolism
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Polyphenols exert beneficial effects in atherosclerosis. The crucial step in atherosclerosis is the recruitment of monocytes to the subendothelial space, induced by endothelial adhesion molecules through the activation of factors such as NF-κB. We studied the effect of a dealcoholised lager beer (DLB) and a dealcoholised dark beer (DDB) on atherosclerotic lesions, and the underlying mechanisms. Dealcoholised beers were administered in the diet (42 ml/kg body weight per d) to 4-week-old male apoE knockout (apoE − / − ) mice for 20 weeks. The atherosclerotic lesions in the thoracic aorta were reduced by 44 % (P = 0·003) and 51 % (P 
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114510004289