Anti-protozoal activity of diamine derivatives

Abstract Ten N -monoalkylated diamines were synthesized and evaluated for in vitro activities against Trichomonas   vaginalis and Giardia   lamblia . Several compounds displayed a good inhibition of parasite growth, with MIC less or equal to 20 μg/mL. N -hexadecil-1,4-butanediamine was found to be t...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2011-02, Vol.65 (1), p.60-62
Main Authors: Giordani, R.B, Araújo, D.P, Duarte, M, Zuanazzi, J.A, Tasca, T, De Almeida, M.V
Format: Article
Language:English
Subjects:
Antiprotozoal Agents - pharmacology
Diamine
Diamines - pharmacology
Giardia lamblia - drug effects
Giardia  lamblia
Internal Medicine
Lipophilicity
Medical Education
Structure-Activity Relationship
Trichomonas vaginalis - drug effects
Trichomonas  vaginalis
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Summary:Abstract Ten N -monoalkylated diamines were synthesized and evaluated for in vitro activities against Trichomonas   vaginalis and Giardia   lamblia . Several compounds displayed a good inhibition of parasite growth, with MIC less or equal to 20 μg/mL. N -hexadecil-1,4-butanediamine was found to be the most active compound in vitro against T.   vaginalis with MIC of 2.5 μg/mL, twice more active in comparison to the reference drug metronidazole (MTZ). Seven of the studied compounds showed a better anti- G.   lamblia activity than MTZ.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2010.10.006