Active participation of cell death in development and organismal homeostasis

The precise, regional execution of programmed cell death is required for the proper patterning and sculpting of the embryonic primordium during animal development. In addition, cell death that is not directly involved in sculpting is also widely observed. The most abundant morphological form of prog...

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Bibliographic Details
Published in:Development, growth & differentiation growth & differentiation, 2011-02, Vol.53 (2), p.125-136
Main Author: Miura, Masayuki
Format: Article
Language:English
Subjects:
Animals
apoptosis
Apoptosis - genetics
Apoptosis - physiology
caspase
Caspases - genetics
Caspases - metabolism
cell death
development
Gene Expression Regulation, Developmental - genetics
Gene Expression Regulation, Developmental - physiology
genetics
Humans
Signal Transduction - genetics
Signal Transduction - physiology
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Summary:The precise, regional execution of programmed cell death is required for the proper patterning and sculpting of the embryonic primordium during animal development. In addition, cell death that is not directly involved in sculpting is also widely observed. The most abundant morphological form of programmed cell death in developing animals is apoptosis, and identification of the apoptotic genetic pathways has enabled the study of apoptosis' regulation and roles during development. Genetic and bio-imaging studies have permitted the study of the active roles of cell death in development and organismal homeostasis.
ISSN:0012-1592
1440-169X
DOI:10.1111/j.1440-169X.2010.01228.x