The T-cell response to Amb a 1 is characterized by 3 dominant epitopes and multiple MHC restriction elements

[...]conjugates containing purified natural Amb a 1 showing reduced IgE binding have been used successfully in clinical trials,3 indicating that the single major ragweed allergen can replace the pollen extract in SIT. [...]the presentation of several Amb a 1 epitopes, including the frequently recogn...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2010-11, Vol.126 (5), p.1068-1071.e2
Main Authors: Jahn-Schmid, Beatrice, PhD, Wopfner, Nicole, PhD, Hubinger, Gudrun, PhD, Asero, Riccardo, MD, Ebner, Christof, MD, Ferreira, Fatima, PhD, Bohle, Barbara, PhD
Format: Article
Language:English
Subjects:
Allergies
Allergy and Immunology
Ambrosia - immunology
Amino acids
Antigens, Plant - immunology
Biological and medical sciences
Cytokines
Desensitization, Immunologic - instrumentation
Epitopes, T-Lymphocyte - immunology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Hypersensitivity - immunology
Immunopathology
Major Histocompatibility Complex - immunology
Medical sciences
Patients
Peptides
Plant Proteins - immunology
Proteins
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
T cell receptors
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Summary:[...]conjugates containing purified natural Amb a 1 showing reduced IgE binding have been used successfully in clinical trials,3 indicating that the single major ragweed allergen can replace the pollen extract in SIT. [...]the presentation of several Amb a 1 epitopes, including the frequently recognized regions Amb a 1202-213 and Amb a 1343-354, was found to be inhibited by antibodies to HLA-DR, HLA-DQ, and HLA-DP molecules (Table I), suggesting highly promiscuous binding of these peptides.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2010.05.038