Comparative mapping of human alphoid satellite DNA repeat sequences in the great apes

Heterochromatic regions of chromosomes contain highly repetitive, tandemly arranged DNA sequences that undergo very rapid variation compared to unique DNA sequences that are predominantly conserved. In this study the chromosomal basis of speciation has been looked at in terms of repeat sequences. We...

Full description

Saved in:
Bibliographic Details
Published in:Genetica 1997-01, Vol.101 (2), p.97-104
Main Authors: Samonte, R V, Ramesh, K H, Verma, R S
Format: Article
Language:English
Subjects:
Animals
Centromere - genetics
Chromosome Mapping
Chromosomes
Chromosomes, Human
Deoxyribonucleic acid
DNA
DNA Probes
DNA, Satellite - chemistry
DNA, Satellite - genetics
Genetic Markers
Genomics
Gorilla gorilla gorilla
Heterochromatin - genetics
Hominidae - genetics
Humans
Karyotyping
Probes
Repetitive Sequences, Nucleic Acid
Satellite DNA
Speciation
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Heterochromatic regions of chromosomes contain highly repetitive, tandemly arranged DNA sequences that undergo very rapid variation compared to unique DNA sequences that are predominantly conserved. In this study the chromosomal basis of speciation has been looked at in terms of repeat sequences. We have hybridized twenty-one chromosome-specific human alphoid satellite DNA probes to metaphase spreads of the chimpanzee (Pan troglodytes), gorilla (Gorilla gorilla), and orangutan (Pongo pygmaeus) to investigate the evolutionary relationship of heterochromatic regions among such hominoid species. The majority of the probes did not hybridize to their corresponding equivalent chromosome but presented hybridization signals on non-corresponding chromosomes. Such observations suggest that rapid changes may have occurred in the ancestral alphoid satellite DNA sequence, resulting in divergence among the great ape species.
ISSN:0016-6707
1573-6857
DOI:10.1023/A:1018360026244