Risk haplotype analysis for bovine paratuberculosis

Paratuberculosis (Johne's disease), caused by Mycobacterium avium subsp. paratuberculosis, is an important disease for bovines, although its genetic basis is poorly understood. In this study, three candidate genes were typed to study the associations between single nucleotide polymorphisms (SNP...

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Bibliographic Details
Published in:Mammalian genome 2009-02, Vol.20 (2), p.124-129
Main Authors: Pinedo, Pablo J, Wang, Chenguang, Li, Yao, Rae, D. Owen, Wu, Rongling
Format: Article
Language:English
Subjects:
Animal Genetics and Genomics
Animals
Biomedical and Life Sciences
Cattle
Cattle Diseases - genetics
Cell Biology
Genetic Predisposition to Disease
Haplotypes
Human Genetics
Life Sciences
Mycobacterium avium
Mycobacterium avium subsp. paratuberculosis
Nod2 Signaling Adaptor Protein - genetics
Paratuberculosis - genetics
Polymorphism, Single Nucleotide
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Summary:Paratuberculosis (Johne's disease), caused by Mycobacterium avium subsp. paratuberculosis, is an important disease for bovines, although its genetic basis is poorly understood. In this study, three candidate genes were typed to study the associations between single nucleotide polymorphisms (SNPs) and paratuberculosis susceptibility (measured in a 1 or 0 form) at the haplotype level. A significant risk haplotype, constructed by a variant allele (C) at the first SNP and a common allele (A) at the second SNP, within the CARD15 gene was detected to trigger genetic effects on paratuberculosis infection in an overdominace manner. Marginally significant haplotypes were identified for the other two genes. The results obtained will provide scientific guidance about the selection and prediction of resistance types in bovines.
ISSN:0938-8990
1432-1777
DOI:10.1007/s00335-008-9167-0