Mutagenicity of octane and tetrasodium pyrophosphate in bacterial reverse mutation (Ames) test

We investigated the genotoxicities or mutagenicities of 2 chemicals (octane and tetrasodium pyrophosphate) with limited toxicological data in spite of their common usage based on Ames reverse mutation test. In this test, treatment of 2 chemicals at each five dose did not induce mutagenicity in Salmo...

Full description

Saved in:
Bibliographic Details
Published in:Journal of toxicological sciences 2010/08/01, Vol.35(4), pp.555-562
Main Authors: Kim, Soo-Jin, Rim, Kyung-Taek, Kim, Hyeon-Yeong, Yang, Jeong-Sun
Format: Article
Language:English
Subjects:
Diphosphates - toxicity
Escherichia coli
Escherichia coli - drug effects
Escherichia coli - genetics
Mutagenicity Tests - methods
Mutagens - toxicity
Octane
Octanes - toxicity
Reverse mutation
Salmonella typhimurium
Salmonella typhimurium - drug effects
Salmonella typhimurium - genetics
Tetrasodium pyrophosphate
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We investigated the genotoxicities or mutagenicities of 2 chemicals (octane and tetrasodium pyrophosphate) with limited toxicological data in spite of their common usage based on Ames reverse mutation test. In this test, treatment of 2 chemicals at each five dose did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA1535, TA1537, and in Escherichia coli WP2uvrA with and without metabolic activation. These results indicate that 2 chemicals do not have mutagenic potentials under the conditions examined in each study. Despite these results, it can affect by inducing inhalation, skin or eye contact, ingestion, and have affected central nervous system as a target organ. It is thus necessary to prepare the local exhaust system and personal protective equipments. Based on this study, we suggest that future studies should be directed toward chronic inhalation, carcinogenic test and so on.
ISSN:0388-1350
1880-3989
1880-3989
DOI:10.2131/jts.35.555