Mutagenicity of octane and tetrasodium pyrophosphate in bacterial reverse mutation (Ames) test

• Published in: Journal of toxicological sciences 2010/08/01, Vol.35(4), pp.555-562
• Main Authors: Kim, Soo-Jin, Rim, Kyung-Taek, Kim, Hyeon-Yeong, Yang, Jeong-Sun
• Format: Article
• Language: English
• Subjects: Diphosphates - toxicity; Escherichia coli; Escherichia coli - drug effects; Escherichia coli - genetics; Mutagenicity Tests - methods; Mutagens - toxicity; Octane; Octanes - toxicity; Reverse mutation; Salmonella typhimurium; Salmonella typhimurium - drug effects; Salmonella typhimurium - genetics; Tetrasodium pyrophosphate
• ISSN: 0388-1350; 1880-3989; 1880-3989
• DOI: 10.2131/jts.35.555

We investigated the genotoxicities or mutagenicities of 2 chemicals (octane and tetrasodium pyrophosphate) with limited toxicological data in spite of their common usage based on Ames reverse mutation test. In this test, treatment of 2 chemicals at each five dose did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA1535, TA1537, and in Escherichia coli WP2uvrA with and without metabolic activation. These results indicate that 2 chemicals do not have mutagenic potentials under the conditions examined in each study. Despite these results, it can affect by inducing inhalation, skin or eye contact, ingestion, and have affected central nervous system as a target organ. It is thus necessary to prepare the local exhaust system and personal protective equipments. Based on this study, we suggest that future studies should be directed toward chronic inhalation, carcinogenic test and so on.