Ecotoxicity of a brominated flame retardant (tetrabromobisphenol A) and its derivatives to aquatic organisms

The large use of tetrabromobisphenol A (B 4BPA) in common products (plastics, electric and electronic equipments) has raised concern about its ecotoxicity. Physical and bio-degradations may lead to the formation of tetrabromobisphenol A derivatives like tri- (B 3BPA), di- (B 2BPA), monobromobispheno...

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Published in:Comparative biochemistry and physiology. Toxicology & pharmacology 2010-11, Vol.152 (4), p.407-412
Main Authors: Debenest, T., Gagné, F., Petit, A.-N., André, C., Kohli, M., Blaise, C.
Format: Article
Language:English
Subjects:
Animals
Anostraca - drug effects
Aquatic Organisms - drug effects
Bacteria - drug effects
Bioassays
Chlorophyta - drug effects
Cnidaria - drug effects
Dose-Response Relationship, Drug
Environmental toxicology
Flame Retardants - toxicity
Oncorhynchus mykiss
Oncorhynchus mykiss - physiology
Polybrominated Biphenyls - chemistry
Polybrominated Biphenyls - toxicity
Tetrabromobisphenol A
Water Pollutants, Chemical - chemistry
Water Pollutants, Chemical - toxicity
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Summary:The large use of tetrabromobisphenol A (B 4BPA) in common products (plastics, electric and electronic equipments) has raised concern about its ecotoxicity. Physical and bio-degradations may lead to the formation of tetrabromobisphenol A derivatives like tri- (B 3BPA), di- (B 2BPA), monobromobisphenol A (B 1BPA) and bisphenol A (BPA). However, little is known about the toxicity of these brominated derivatives. An appraisal on the ecotoxicity of B 4BPA and its derivatives was carried out with several bioassays representing organisms (bacteria, algae, micro-invertebrates and fish) of different taxonomic groups present in aquatic ecosystems. Endpoint values showed that B 4BPA was significantly less toxic than the other chemicals when tested with the Microtox and algal asssays. A similar trend was observed with other bioassays for BPA. One of the brominated derivatives was particularly toxic: B 2BPA. The LuminoTox assay and the rainbow trout hepatocytes assay reported the most significant toxicity for this derivative. Its toxicity was also significantly higher than the other compounds barring B 3BPA when tested with the micro-crustacean test.
ISSN:1532-0456
1878-1659
DOI:10.1016/j.cbpc.2010.06.009