Nigrostriatal dysfunction in patients with amyotrophic lateral sclerosis and parkinsonism

Abstract The pathomechanism of amyotrophic lateral sclerosis (ALS) with parkinsonism (ALS-P) has not been clarified. We report two patients with ALS-P who showed dysfunction of the nigrostriatal system. The first patient showed tremor dominant, asymmetric parkinsonism which was more severe on the ri...

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Bibliographic Details
Published in:Journal of the neurological sciences 2011-02, Vol.301 (1), p.12-13
Main Authors: Park, Hee Kyung, Lim, Young-Min, Kim, Jae Seung, Lee, Myoung C, Kim, Seung Min, Kim, Bum Joon, Kim, Kwang-Kuk
Format: Article
Language:English
Subjects:
Aged
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - complications
Amyotrophic Lateral Sclerosis - diagnostic imaging
Amyotrophic Lateral Sclerosis - physiopathology
Antiparkinson Agents - therapeutic use
Biological and medical sciences
Corpus Striatum - diagnostic imaging
Corpus Striatum - physiopathology
Fluorine Radioisotopes
Gait Disorders, Neurologic - etiology
Gait Disorders, Neurologic - physiopathology
Humans
Levodopa - therapeutic use
Male
Medical sciences
Middle Aged
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Parkinson's disease
Parkinsonian Disorders - diagnostic imaging
Parkinsonian Disorders - drug therapy
Parkinsonian Disorders - etiology
Parkinsonian Disorders - physiopathology
Positron emission tomography
Presynaptic Terminals - physiology
Putamen - diagnostic imaging
Putamen - physiopathology
Radiopharmaceuticals
Substantia Nigra - diagnostic imaging
Substantia Nigra - physiopathology
Tremor - drug therapy
Tremor - etiology
Tremor - physiopathology
Tropanes
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Summary:Abstract The pathomechanism of amyotrophic lateral sclerosis (ALS) with parkinsonism (ALS-P) has not been clarified. We report two patients with ALS-P who showed dysfunction of the nigrostriatal system. The first patient showed tremor dominant, asymmetric parkinsonism which was more severe on the right side, while the second patient exhibited predominant freezing of gait. Both patients showed reduced uptake of [18 F] N-(3-fluoropropyl)-2ß-carbon ethoxy-3ß-(4-iodophenyl) nortropane (18 F-FP-CIT) in the posterior parts of bilateral putamina on positron emission tomography (PET). Based on our PET findings, we suggest that presynaptic nigrostriatal dysfunction may be involved in the pathomechanism of parkinsonism combined with ALS.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2010.11.017