Anaphylactic Reaction to Different Gonadotropin-Releasing Hormone Agonists for the Treatment of Endometriosis

Abstract Anaphylactic reactions to gonadotropin-releasing hormone (GnRH) agonists are exceedingly rare, but if they occur, they can be life threatening. This case describes a 33-year-old patient with endometriosis who developed an acute allergic reaction on leuprolide (Lucrin) administration. Althou...

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Bibliographic Details
Published in:The American journal of the medical sciences 2011-03, Vol.341 (3), p.240-242
Main Authors: Lüchinger, Annemarie B., MD, Mijatovic, Velja, MD, PhD, Hompes, Peter G.A., MD, PhD, Rustemeyer, Thomas, MD, PhD
Format: Article
Language:English
Subjects:
Adult
Anaphylaxis
Anaphylaxis - chemically induced
Anaphylaxis - diagnosis
Anaphylaxis - drug therapy
Anti-Allergic Agents - therapeutic use
Biological and medical sciences
Clemastine - therapeutic use
Diagnosis, Differential
Endometriosis
Endometriosis - drug therapy
Female
Female genital diseases
Fundamental and applied biological sciences. Psychology
General aspects
Gonadotropin-Releasing Hormone - agonists
Gonadotropin-Releasing Hormone - therapeutic use
Goserelin
Goserelin - administration & dosage
Goserelin - adverse effects
Gynecology. Andrology. Obstetrics
Histamine H1 Antagonists - therapeutic use
Humans
Hypersensitivity
Internal Medicine
Leuprolide
Leuprolide - administration & dosage
Leuprolide - adverse effects
Medical sciences
Non tumoral diseases
Vertebrates: endocrinology
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Summary:Abstract Anaphylactic reactions to gonadotropin-releasing hormone (GnRH) agonists are exceedingly rare, but if they occur, they can be life threatening. This case describes a 33-year-old patient with endometriosis who developed an acute allergic reaction on leuprolide (Lucrin) administration. Although skin tests with the replacement goserelin (Zoladex) were negative, usage of this medication resulted in a similar allergic reaction. This is the first case report that shows that, in case of a proven allergy to one GnRH agonist, a switch to another GnRH agonist should not be made even if allergy tests are negative for this medication.
ISSN:0002-9629
1538-2990
DOI:10.1097/MAJ.0b013e31820094da