BAG3 (BCL2-associated athanogene 3) interacts with MMP-2 to positively regulate invasion by ovarian carcinoma cells

Abstract BAG3 (BCL2-associated athanogene 3) is a member of the BAG family proteins, which interact with and regulate Hsp70. Our aim in the present study was to correlate BAG3 expression in ovarian cancer with invasion and progression-free survival. We found that BAG3 interacts with MMP2 in cultured...

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Bibliographic Details
Published in:Cancer letters 2011-04, Vol.303 (1), p.65-71
Main Authors: Suzuki, Miwa, Iwasaki, Masahiro, Sugio, Asuka, Hishiya, Akinori, Tanaka, Ryoichi, Endo, Toshiaki, Takayama, Shinichi, Saito, Tsuyoshi
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - biosynthesis
Adaptor Proteins, Signal Transducing - genetics
Adaptor Proteins, Signal Transducing - metabolism
Apoptosis Regulatory Proteins - genetics
Apoptosis Regulatory Proteins - metabolism
BAG3
Carcinoma, Ovarian Epithelial
Carrier Proteins
Cell Line, Tumor
Cell Movement
Cellular biology
Disease-Free Survival
Female
Gene Knockdown Techniques
Hematology, Oncology and Palliative Medicine
Humans
Invasion
Matrix Metalloproteinase 2 - biosynthesis
Matrix Metalloproteinase 2 - genetics
Matrix Metalloproteinase 2 - metabolism
Metastasis
MMP2
Motility
Neoplasm Invasiveness
Neoplasms, Glandular and Epithelial - genetics
Neoplasms, Glandular and Epithelial - metabolism
Neoplasms, Glandular and Epithelial - pathology
Ovarian cancer
Ovarian carcinoma
Ovarian Neoplasms - genetics
Ovarian Neoplasms - metabolism
Ovarian Neoplasms - pathology
Proteins
RNA polymerase
Signal transduction
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Summary:Abstract BAG3 (BCL2-associated athanogene 3) is a member of the BAG family proteins, which interact with and regulate Hsp70. Our aim in the present study was to correlate BAG3 expression in ovarian cancer with invasion and progression-free survival. We found that BAG3 interacts with MMP2 in cultured ovarian cancer cells, and that knockdown of BAG3 expression downregulated MMP2 expression and diminished cell motility and invasiveness. The incidence of BAG3 positivity was significantly higher at advanced clinical stages of ovarian cancer than at early stages. We suggest that BAG3 binds to MMP2 to positively regulate the process of cell invasion.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2011.01.019