Protective effect of bicyclol on lipopolysaccharide-induced acute lung injury in mice

Abstract Bicyclol is synthesized based on schisandrin, which is one of the main active components of Chinese herb Fructus Schisandrae. The purpose of this study is to investigate whether bicyclol has a beneficial effect on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. Bicyclol wa...

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Published in:Pulmonary pharmacology & therapeutics 2011-04, Vol.24 (2), p.240-246
Main Authors: Luo, Ying, Zhang, Bo, Xu, Dun-Quan, Liu, Yi, Dong, Ming-Qing, Zhao, Peng-Tao, Li, Zhi-Chao
Format: Article
Language:English
Subjects:
Acute lung injury
Acute Lung Injury - mortality
Acute Lung Injury - prevention & control
Animals
Bicyclol
Biphenyl Compounds - administration & dosage
Biphenyl Compounds - pharmacology
Cytokines - metabolism
Disease Models, Animal
Dose-Response Relationship, Drug
Lipopolysaccharide
Lipopolysaccharides - toxicity
Male
Medical Education
Mice
Mice, Inbred BALB C
NF-kappa B - metabolism
NF-κB
Peroxidase - metabolism
Phosphorylation - drug effects
Pulmonary/Respiratory
Time Factors
Transcription Factor RelA - metabolism
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Summary:Abstract Bicyclol is synthesized based on schisandrin, which is one of the main active components of Chinese herb Fructus Schisandrae. The purpose of this study is to investigate whether bicyclol has a beneficial effect on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. Bicyclol was given to mice by gavage for three times. ALI was induced by vena caudalis injection of LPS. The last dose of bicyclol was administrated 1 h before LPS given. Mice in each group were sacrificed at different time point after LPS administration. As revealed by survival study, pretreatment with high doses of bicyclol reduced the mortality of mice from ALI. Bicyclol pretreatment significantly improved LPS-induced lung pathological changes, inhibited myeloperoxidase (MPO) activity, and reduced lung/body and lung wet/dry weight ratios. Bicyclol also inhibited the release of TNF-α, IL-1β and HMGB1, whereas simultaneously increased the expression of IL-10. Furthermore, the phosphorylation level of NF-κB p65 was markedly decreased by bicyclol. Taken together, our study showed that bicyclol improves survival rate and attenuates LPS-induced ALI. The protective mechanism may be due to the inhibition of NF-κB activation and regulation of cytokine secretion.
ISSN:1094-5539
1522-9629
DOI:10.1016/j.pupt.2010.12.005