False-positive uptake on 2-[18 F]-fluoro-2-deoxy- d- glucose (FDG) positron-emission tomography/computed tomography (PET/CT) in oncological imaging

With the increasing utilization of integrated positron-emission tomography/computed tomography (PET/CT) using the glucose analogue 2-[18 F]-fluoro-2-deoxy- d- glucose (FDG) in oncological imaging, it is important for radiologists and nuclear medicine physicians to be aware that FDG uptake is not spe...

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Bibliographic Details
Published in:Clinical radiology 2011-04, Vol.66 (4), p.366-382
Main Authors: Culverwell, A.D, Scarsbrook, A.F, Chowdhury, F.U
Format: Article
Language:English
Subjects:
Biological and medical sciences
False Positive Reactions
Fluorodeoxyglucose F18 - pharmacokinetics
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Miscellaneous. Technology
Neoplasms - diagnostic imaging
Neoplasms - metabolism
Positron-Emission Tomography - methods
Radiology
Radionuclide investigations
Radiopharmaceuticals - pharmacokinetics
Tomography, X-Ray Computed - methods
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Summary:With the increasing utilization of integrated positron-emission tomography/computed tomography (PET/CT) using the glucose analogue 2-[18 F]-fluoro-2-deoxy- d- glucose (FDG) in oncological imaging, it is important for radiologists and nuclear medicine physicians to be aware that FDG uptake is not specific for malignancy, as many different physiological variants and benign pathological conditions can also exhibit increased glucose metabolism. Such false-positive FDG uptake often arises outside the area of primary interest and may mimic malignant disease, thereby confounding accurate interpretation of PET/CT studies. With the use of illustrative clinical cases, this article will provide a systematic overview of potential interpretative pitfalls and illustrate how such unexpected findings can be appropriately evaluated.
ISSN:0009-9260
1365-229X
DOI:10.1016/j.crad.2010.12.004