Performance of radiological methods in diagnosing hepatocellular carcinoma preoperatively in a recipient of living related liver transplantation: comparison with step section histopathology

Purpose The aim of the present study was to evaluate the performance of multidetector-row CT (MDCT) and magnetic resonance imaging (MRI) in diagnosing hepatocellular carcinoma (HCC) preoperatively in living related liver transplantation (LRLT) recipients with liver cirrhosis and HCC. Materials and m...

Full description

Saved in:
Bibliographic Details
Published in:Japanese journal of radiology 2011-02, Vol.29 (2), p.129-137
Main Authors: Hirakawa, Masakazu, Yoshimitsu, Kengo, Irie, Hiroyuki, Tajima, Tsuyoshi, Nishie, Akihiro, Asayama, Yoshiki, Ishigami, Kousei, Kakihara, Daisuke, Taketomi, Akinobu, Aishima, Shin-ichi, Honda, Hiroshi
Format: Article
Language:English
Subjects:
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - diagnostic imaging
Carcinoma, Hepatocellular - pathology
Female
Humans
Imaging
Liver Cirrhosis - diagnosis
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - pathology
Liver Neoplasms - diagnosis
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - pathology
Liver Transplantation
Living Donors
Magnetic Resonance Imaging - methods
Male
Medicine
Medicine & Public Health
Nuclear Medicine
Original Article
Predictive Value of Tests
Preoperative Period
Radiology
Radiotherapy
ROC Curve
Sensitivity and Specificity
Tomography, X-Ray Computed - methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose The aim of the present study was to evaluate the performance of multidetector-row CT (MDCT) and magnetic resonance imaging (MRI) in diagnosing hepatocellular carcinoma (HCC) preoperatively in living related liver transplantation (LRLT) recipients with liver cirrhosis and HCC. Materials and methods A total of 25 LRLT recipients with 89 pathologically proved HCCs underwent dynamic 4-row MDCT (5 mm collimation) and MRI within 1 month before LRLT. The images were reviewed for the diagnosis of HCC on a tumor-by-tumor basis by three observers independently and randomly using explanted specimens as the gold standard. The diagnostic accuracy of these techniques in the detection of HCC was assessed with alternative free response receiver operating characteristic (ROC) analysis. The sensitivity and positive predictive values were evaluated. Results The average values of the area under the ROC curve (Az) of MRI images were higher than those obtained with MDCT; however, no significant difference was observed ( P > 0.05). The overall sensitivity of HCC with MRI was higher than that with MDCT, especially in the case of HCCs
ISSN:1867-1071
1867-108X
DOI:10.1007/s11604-010-0528-8