Distribution of CB2 cannabinoid receptor in adult rat retina

Cannabinoid effects are mediated through two receptors, CB1 and CB2. In the retina CB1 has been reported in bipolar cells, gabaergic amacrine cells, horizontal cells, and inner plexiform layer. CB2 receptor mRNA localization was shown in photoreceptors, inner nuclear layer, and ganglion cell layer b...

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Bibliographic Details
Published in:Synapse (New York, N.Y.) N.Y.), 2011-05, Vol.65 (5), p.388-392
Main Authors: López, Ester M., Tagliaferro, Patricia, Onaivi, Emmanuel S., López-Costa, Juan J.
Format: Article
Language:English
Subjects:
Amacrine cells
Animals
Bipolar cells
Cannabinoid CB1 receptors
Cannabinoid CB2 receptors
cannabinoid receptor
CB2
Epithelium
Fibers
gamma -Aminobutyric acid
Horizontal cells
Immunocytochemistry
Male
mRNA
Neurons - metabolism
Photoreceptors
Polymerase chain reaction
rat
Rats
Rats, Sprague-Dawley
Receptor, Cannabinoid, CB2 - metabolism
Retina
Retina - cytology
Retina - metabolism
Retinal ganglion cells
Synapses
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Summary:Cannabinoid effects are mediated through two receptors, CB1 and CB2. In the retina CB1 has been reported in bipolar cells, gabaergic amacrine cells, horizontal cells, and inner plexiform layer. CB2 receptor mRNA localization was shown in photoreceptors, inner nuclear layer, and ganglion cell layer by using RT‐PCR. The aim of this work was to localize CB2 receptor in the rat retina by using immunocytochemistry. Our results showed that CB2 receptor was localized in retinal pigmentary epithelium, inner photoreceptor segments, horizontal and amacrine cells, cells localized in ganglion cell layer, and in fibers of inner plexiform layer. These results are in agreement with studies using RT‐PCR and provide some additional information about the distribution of CB2 receptor. Further studies are needed to clarify the role of this cannabinoid receptor in the retina. Synapse, 2010. © 2010 Wiley‐Liss, Inc.
ISSN:0887-4476
1098-2396
1098-2396
DOI:10.1002/syn.20856