Review: Preclinical studies on placenta-derived cells and amniotic membrane: An update

Abstract Recent years have seen considerable advances in our knowledge of the biology and properties of stem/progenitor cells isolated from placental tissues. This has encouraged researchers to address the potential effects of these cells in animal models of different diseases, resulting in increasi...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2011-03, Vol.32, p.S186-S195
Main Authors: Parolini, O, Caruso, M
Format: Article
Language:English
Subjects:
Amnion - cytology
Amnion - transplantation
Amniotic membrane
Animals
Cell Transplantation - methods
Disease Models, Animal
Female
Humans
Internal Medicine
Obstetrics and Gynecology
Placenta
Placenta - cytology
Placenta-derived cells
Pregnancy
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Summary:Abstract Recent years have seen considerable advances in our knowledge of the biology and properties of stem/progenitor cells isolated from placental tissues. This has encouraged researchers to address the potential effects of these cells in animal models of different diseases, resulting in increasing expectations regarding their possible utility for cell-based therapeutic applications. This rapidly evolving research field is also enriched by studies aimed at expanding the use of the whole amniotic membrane (AM), a well-known surgical material, for pathological conditions other than those tested so far and for which clinical applications already exist. In this review, we provide an update on studies that have been performed with placenta-derived cells and fragments of the entire AM to validate their potential clinical applications in a variety of diseases, in particular those associated with degenerative processes induced by inflammatory and fibrotic mechanisms. We also offer, as far as possible, insight into the interpretation and suggested mechanisms to explain the most important outcomes achieved to date.
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2010.12.016