Signal characteristics of focal bone marrow lesions in patients with multiple myeloma using whole body T1w-TSE, T2w-STIR and diffusion-weighted imaging with background suppression

Objective This study analyses the diagnostic potential of Diffusion-Weighted Imaging with Background Suppression (DWIBS) in the detection of focal bone marrow lesions from multiple myeloma. The signal and contrast properties of DWIBS are evaluated in correlation with the serum concentration of M-com...

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Bibliographic Details
Published in:European radiology 2011-04, Vol.21 (4), p.857-862
Main Authors: Sommer, Gregor, Klarhöfer, Markus, Lenz, Claudia, Scheffler, Klaus, Bongartz, Georg, Winter, Leopold
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Blood tests
Bone marrow
Bone Marrow - pathology
Bone Marrow Cells - cytology
Diagnostic Radiology
Diffusion Magnetic Resonance Imaging - methods
Humans
Image Interpretation, Computer-Assisted - methods
Imaging
Internal Medicine
Interventional Radiology
Magnetic Resonance Imaging - methods
Medicine
Medicine & Public Health
Middle Aged
Multiple myeloma
Multiple Myeloma - diagnostic imaging
Multiple Myeloma - pathology
Musculoskeletal
Neuroradiology
Osteoporosis
Radiography
Radiology
Recurrence
Retrospective Studies
Ultrasound
Whole Body Imaging
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Summary:Objective This study analyses the diagnostic potential of Diffusion-Weighted Imaging with Background Suppression (DWIBS) in the detection of focal bone marrow lesions from multiple myeloma. The signal and contrast properties of DWIBS are evaluated in correlation with the serum concentration of M-component (MC) and compared with established T1- and T2-weighted sequences. Methods Data from 103 consecutive studies in 81 patients are analysed retrospectively. Signal intensities and apparent Diffusion Coefficients (ADC) of 79 focal lesions in the lumbar spine or pelvis of 38 patients are determined and contrast-to-noise-ratio (CNR) is calculated. Data from patients with low (20 g/dL) MC are evaluated separately. Results Signal intensities of focal myeloma lesions on T2w-STIR vary significantly depending on the MC, which leads to a loss in CNR in patients with high MC. No signal variation is observed for T1w-TSE and DWIBS. The CNR values provided by DWIBS in patients with high MC are slightly higher than those of T2w-STIR. ADC values in patients with low MC are significantly higher than in patients with high MC. Conclusion Whole-body DWIBS has the potential to improve the conspicuity of focal myeloma lesions and provides additional biological information by ADC quantification.
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-010-1950-0