Dynamic Metabolons

The assembly and disassembly of enzymes complexes may differentiate plant defense responses to insect attack and fungal infection. The metabolic activities of higher organisms are highly coordinated. At the cellular level, compartmentalization into organelles and substructures thereof optimizes the...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2010-12, Vol.330 (6009), p.1328-1329
Main Author: Moeller, Birger Lindberg
Format: Article
Language:English
Subjects:
Biochemical pathways
Cyanides
Cytochromes
Dynamics
Enzymes
Fungal infections
Glucosides
Glucosinolates
Innate immunity
Oximes
PERSPECTIVES
Phytophagous insects
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Summary:The assembly and disassembly of enzymes complexes may differentiate plant defense responses to insect attack and fungal infection. The metabolic activities of higher organisms are highly coordinated. At the cellular level, compartmentalization into organelles and substructures thereof optimizes the concentration of substrates targeted by enzymes. At the molecular level, further substrate concentration is gained by the formation of multienzyme complexes—so-called metabolons. The protein constituents of a metabolon are held together by noncovalent interactions and often stabilized by membrane anchoring. A metabolon allows the direct passage of a product from one enzymatic reaction to a consecutive enzyme in a metabolic pathway. Such channeling of intermediates limits their diffusion into the surrounding milieu, maintains separate pools of intermediates, facilitates fast turnover of labile or toxic intermediates, and may prevent undesired crosstalk between different metabolic pathways ( 1 , 2 ).
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1194971