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Dynamic Metabolons
The assembly and disassembly of enzymes complexes may differentiate plant defense responses to insect attack and fungal infection. The metabolic activities of higher organisms are highly coordinated. At the cellular level, compartmentalization into organelles and substructures thereof optimizes the...
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| Published in: | Science (American Association for the Advancement of Science) 2010-12, Vol.330 (6009), p.1328-1329 |
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| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c361t-364fc93858428e4f884f47e69af078af77aa30e27828c5586488020051d324263 |
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| cites | cdi_FETCH-LOGICAL-c361t-364fc93858428e4f884f47e69af078af77aa30e27828c5586488020051d324263 |
| container_end_page | 1329 |
| container_issue | 6009 |
| container_start_page | 1328 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 330 |
| creator | Moeller, Birger Lindberg |
| description | The assembly and disassembly of enzymes complexes may differentiate plant defense responses to insect attack and fungal infection.
The metabolic activities of higher organisms are highly coordinated. At the cellular level, compartmentalization into organelles and substructures thereof optimizes the concentration of substrates targeted by enzymes. At the molecular level, further substrate concentration is gained by the formation of multienzyme complexes—so-called metabolons. The protein constituents of a metabolon are held together by noncovalent interactions and often stabilized by membrane anchoring. A metabolon allows the direct passage of a product from one enzymatic reaction to a consecutive enzyme in a metabolic pathway. Such channeling of intermediates limits their diffusion into the surrounding milieu, maintains separate pools of intermediates, facilitates fast turnover of labile or toxic intermediates, and may prevent undesired crosstalk between different metabolic pathways (
1
,
2
). |
| doi_str_mv | 10.1126/science.1194971 |
| format | article |
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The metabolic activities of higher organisms are highly coordinated. At the cellular level, compartmentalization into organelles and substructures thereof optimizes the concentration of substrates targeted by enzymes. At the molecular level, further substrate concentration is gained by the formation of multienzyme complexes—so-called metabolons. The protein constituents of a metabolon are held together by noncovalent interactions and often stabilized by membrane anchoring. A metabolon allows the direct passage of a product from one enzymatic reaction to a consecutive enzyme in a metabolic pathway. Such channeling of intermediates limits their diffusion into the surrounding milieu, maintains separate pools of intermediates, facilitates fast turnover of labile or toxic intermediates, and may prevent undesired crosstalk between different metabolic pathways (
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2
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The metabolic activities of higher organisms are highly coordinated. At the cellular level, compartmentalization into organelles and substructures thereof optimizes the concentration of substrates targeted by enzymes. At the molecular level, further substrate concentration is gained by the formation of multienzyme complexes—so-called metabolons. The protein constituents of a metabolon are held together by noncovalent interactions and often stabilized by membrane anchoring. A metabolon allows the direct passage of a product from one enzymatic reaction to a consecutive enzyme in a metabolic pathway. Such channeling of intermediates limits their diffusion into the surrounding milieu, maintains separate pools of intermediates, facilitates fast turnover of labile or toxic intermediates, and may prevent undesired crosstalk between different metabolic pathways (
1
,
2
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The metabolic activities of higher organisms are highly coordinated. At the cellular level, compartmentalization into organelles and substructures thereof optimizes the concentration of substrates targeted by enzymes. At the molecular level, further substrate concentration is gained by the formation of multienzyme complexes—so-called metabolons. The protein constituents of a metabolon are held together by noncovalent interactions and often stabilized by membrane anchoring. A metabolon allows the direct passage of a product from one enzymatic reaction to a consecutive enzyme in a metabolic pathway. Such channeling of intermediates limits their diffusion into the surrounding milieu, maintains separate pools of intermediates, facilitates fast turnover of labile or toxic intermediates, and may prevent undesired crosstalk between different metabolic pathways (
1
,
2
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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2010-12, Vol.330 (6009), p.1328-1329 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_855689278 |
| source | Science Magazine; JSTOR Archival Journals and Primary Sources Collection; Alma/SFX Local Collection |
| subjects | Biochemical pathways Cyanides Cytochromes Dynamics Enzymes Fungal infections Glucosides Glucosinolates Innate immunity Oximes PERSPECTIVES Phytophagous insects |
| title | Dynamic Metabolons |
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