Effect of an antioxidant functional food beverage on exercise-induced oxidative stress: A long-term and large-scale clinical intervention study

Abstract The efficacy of long-term intake of a novel functional food supplement Funciona™ containing vitamins and juiced fruits was evaluated in order to assess the net effect of physical activity and antioxidant potentials in healthy older adult population. The long-term (2 years) and large-scale (...

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2010-11, Vol.278 (1), p.101-111
Main Authors: Muñoz, Maria E, Galan, Ana I, Palacios, Encarna, Diez, Maria A, Muguerza, Begoña, Cobaleda, Cesar, Calvo, Jose I, Aruoma, Okezie I, Sanchez-Garcia, Isidro, Jimenez, Rafael
Format: Article
Language:English
Subjects:
Adults
Aged
Aged, 80 and over
Antioxidant functional food supplementation
Antioxidant vitamins
Antioxidants
Antioxidants - pharmacology
Ascorbic Acid - blood
Beverages
Blood
Clinical study
Cohort Studies
Dietary Supplements
Eating - physiology
Elderly
Emergency
Female
Functional foods
Glutathione
Glutathione - blood
Guanine - analogs & derivatives
Guanine - blood
Humans
Male
Middle Aged
Oxidative stress
Oxidative Stress - drug effects
Oxidative Stress - physiology
Physical Exertion - physiology
Protein Carbonylation - physiology
Proteins
Regular exercise
Stresses
Thiobarbituric Acid Reactive Substances - metabolism
Vitamin C
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Summary:Abstract The efficacy of long-term intake of a novel functional food supplement Funciona™ containing vitamins and juiced fruits was evaluated in order to assess the net effect of physical activity and antioxidant potentials in healthy older adult population. The long-term (2 years) and large-scale (400 older adult subjects) interventional study was based on both moderate-intensity exercise practice and concurrent supplementation. Sustained exercise-induced oxidative stress as reflected in significantly increased blood thiobarbituric acid-reactive substances (TBARS) (+15%), protein carbonyl groups (PC) (+18%) and oxidized glutathione (GSSG) (+112%) concentrations, and leukocyte 8-OHdG contents (23%). Exercise decreased the reduced/oxidized glutathione (GSH/GSSG) molar ratio (−43%) and plasma vitamin C levels (−22%). Supplementation with Funciona™ was significant in preventing oxidative damage to lipid, protein and DNA, and normalizing blood GSSG, GSH/GSSG and vitamin C levels. Thus daily intake of the antioxidant functional beverage counteracts the exercise-induced oxidative stress in free-living older subjects, and might be necessary to restore impaired antioxidant balance due long-term regular exercise.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2009.10.015