Synthesis and In-Vitro Antimycobacterial Studies of Cysteine Capped silver Nano-Particles

Nanoparticles are widely used for targeted drug delivery and for other biomedical applications. Particularly silver nanoparticles have gained much importance in nanobiotechnology due to their antimicrobial activity. In the present study, a novel nanobioconjugate of silver and cysteine has been prepa...

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Bibliographic Details
Published in:Synthesis and reactivity in inorganic, metal-organic, and nano-metal chemistry metal-organic, and nano-metal chemistry, 2009-11, Vol.39 (9), p.554-558
Main Authors: Varghese, Mithun V., Dhumal, Ravindra S., Patil, Sharvil S., Paradkar, Anant R., Khanna, Pawan K.
Format: Article
Language:English
Subjects:
Capping
Cysteine
mycobacterium tuberculae
nanobioconjugate
Nanocomposites
Nanomaterials
Nanoparticles
Nanostructure
Silver
silver nano-particle
Sodium
Synthesis
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Summary:Nanoparticles are widely used for targeted drug delivery and for other biomedical applications. Particularly silver nanoparticles have gained much importance in nanobiotechnology due to their antimicrobial activity. In the present study, a novel nanobioconjugate of silver and cysteine has been prepared to study the antimycobacterial activity. This is the first ever study wherein Ag nano-particles have been capped by cysteine, which is a bioactive stablizer. The cysteine capped silver nano-particles were synthesized by reduction of silver nitrate using sodium borohydride as a reducing agent and cysteine as a capping agent (stabilizer). As-prepared silver nano-particles were characterized by Surface plasmon resonance by UV-Visible measurements, FTIR spectroscopy and particle size distribution measurements. The so-prepared Cy bound silver nano-particles (17ppm Ag in Cy) enhanced the anti mycobacterial activity of cysteine from 10 ppm to about 6 ppm similar to that is observed for nano-particles alone.
ISSN:1553-3174
1553-3182
DOI:10.1080/15533170903327869