Electrophysiological Analysis of Context Effects in Alzheimer's Disease

Event-related potentials elicited by semantically associated and unassociated word pairs embedded in congruous and semantically anomalous spoken sentences were recorded from patients with Alzheimer's disease (AD) and healthy older and young controls as a means of examining the nature, time cour...

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Bibliographic Details
Published in:Neuropsychology 2003-04, Vol.17 (2), p.187-201
Main Authors: Schwartz, Tanya J, Federmeier, Kara D, Van Petten, Cyma, Salmon, David P, Kutas, Marta
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Age Differences
Aged
Aged, 80 and over
Aging
Aging - physiology
Algorithms
Alzheimer Disease - physiopathology
Alzheimer's Disease
Audiometry
Biological and medical sciences
Brain - physiology
Contextual Associations
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Electrophysiology
Evoked Potentials - physiology
Female
Human
Humans
Lexical Access
Male
Medical sciences
Middle Aged
Neurology
Organic mental disorders. Neuropsychology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Reading
Semantic Memory
Sentence Structure
Words (Phonetic Units)
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Summary:Event-related potentials elicited by semantically associated and unassociated word pairs embedded in congruous and semantically anomalous spoken sentences were recorded from patients with Alzheimer's disease (AD) and healthy older and young controls as a means of examining the nature, time course, and relation between word and sentence context effects. All groups demonstrated lexical priming in nonsensical sentences, but it was earlier in the young (200-600 ms) than in the older controls (600-800 ms), and even later in the probable AD patients (800-1,000 ms). Moreover, processing in both the elderly and AD groups benefited disproportionately from a meaningful sentence context. The results do not accord well with either a strictly structural or a strictly functional account of the semantic impairments in AD.
ISSN:0894-4105
1931-1559
DOI:10.1037/0894-4105.17.2.187