Serum Adiponectin Levels in High School Girls with Polycystic Ovary Syndrome and Hyperandrogenism

Abstract Objective To compare the serum adiponectin levels together with metabolic and hormonal parameters among teenage girls at the early onset of polycystic ovary syndrome (PCOS) and hyperandrogenism with controls. Design Prospective study. Settings Education and research hospital, outpatient gyn...

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Bibliographic Details
Published in:Journal of pediatric & adolescent gynecology 2011-04, Vol.24 (2), p.90-93
Main Authors: Yasar, L, Ekin, M, Gedikbasi, A, Erturk, A.D, Savan, K, Ozdemir, A, Temur, M
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - blood
Adolescent
Blood Glucose - metabolism
BMI
Body Mass Index
Female
Humans
Hyperandrogenism
Hyperandrogenism - blood
Insulin - blood
Obstetrics and Gynecology
PCOS
Pediatrics
Polycystic Ovary Syndrome - blood
Prospective Studies
Triglycerides - blood
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Summary:Abstract Objective To compare the serum adiponectin levels together with metabolic and hormonal parameters among teenage girls at the early onset of polycystic ovary syndrome (PCOS) and hyperandrogenism with controls. Design Prospective study. Settings Education and research hospital, outpatient gynecological endocrinology clinic. Participants Four hundred seventy-nine teenage girls from a school of nursing were interviewed for the signs and symptoms of PCOS. Among them, 42 cases who had a definitive diagnosis of PCOS with hyperandrogenism based on Rotterdam diagnostic criteria were recruited for the study and other causes of hyperandrogenemia had been excluded. The controls were recruited from regularly cycling healthy teenage girls from the same high school of nursing; none of those who agreed to join the study met any of the diagnostic criteria for PCOS (n = 44). Interventions Cases were selected as group I: PCOS with body mass index (BMI) 25 kg/m2 (n = 22), group III: Controls with BMI 25 kg/m2 (n = 23). Serum adiponectin, metabolic and hormonal parameters were compared in PCOS patients with BMI matched controls. Main Outcome Measures Difference of serum adiponectin levels, metabolic and hormonal parameters between teenage girls with PCOS and controls. Results Serum adiponectin levels were not significantly different in group I and group II. Serum adiponectin levels were significantly decreased in group I and group II compared with both control groups (III and IV). Conclusion Serum adiponectin levels were lower in teenage girls with PCOS and this reduction was independent from BMI.
ISSN:1083-3188
1873-4332
DOI:10.1016/j.jpag.2010.11.003