Changing demographics in REM sleep behavior disorder: Possible effect of autoimmunity and antidepressants

Abstract Background Rapid eye movement (REM) sleep behavior disorder (RBD) has been described predominantly in elderly men and in association with neurodegenerative disease. But an increasing proportion of cases in recent reports and in clinical practice do not fit this description; thus we sought t...

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Bibliographic Details
Published in:Sleep medicine 2011-03, Vol.12 (3), p.278-283
Main Authors: Ju, Yo-El, Larson-Prior, Linda, Duntley, Stephen
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Distribution
Age of Onset
Aged
Antidepressant
Antidepressive Agents - adverse effects
Autoimmune
Autoimmune Diseases - epidemiology
Dementia
Female
Humans
Incidence
Male
Middle Aged
Narcolepsy
Narcolepsy - chemically induced
Narcolepsy - epidemiology
Narcolepsy - immunology
Neurodegenerative Diseases - epidemiology
Neurology
Polysomnography
Prevalence
RBD
REM Sleep Behavior Disorder - chemically induced
REM Sleep Behavior Disorder - epidemiology
REM Sleep Behavior Disorder - immunology
Retrospective Studies
Sex Distribution
Sleep Medicine
Synucleinopathy
Young Adult
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Summary:Abstract Background Rapid eye movement (REM) sleep behavior disorder (RBD) has been described predominantly in elderly men and in association with neurodegenerative disease. But an increasing proportion of cases in recent reports and in clinical practice do not fit this description; thus we sought to describe a current RBD population and possibly identify new subgroups with RBD. Methods Records of 115 consecutive patients with polysomnogram-confirmed RBD at an academic sleep center were retrospectively reviewed. Results Male to female ratio was 2:1, and 1.25:1 for early-onset (age
ISSN:1389-9457
1878-5506
DOI:10.1016/j.sleep.2010.07.022