FGF21 reloaded: challenges of a rapidly growing field

Fibroblast growth factor 21 (FGF21) is a pleiotropic hormone-like protein and a major metabolic regulator. However, several key aspects of FGF21 biology remain poorly understood. Indeed, the list of controversies in the FGF21 field spans a variety of topics, from basic matters such as the anatomic d...

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Bibliographic Details
Published in:Trends in endocrinology and metabolism 2011-03, Vol.22 (3), p.81-86
Main Authors: Kharitonenkov, Alexei, Larsen, Philip
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Endocrinology & Metabolism
Fibroblast Growth Factors - analysis
Fibroblast Growth Factors - genetics
Fibroblast Growth Factors - physiology
Fundamental and applied biological sciences. Psychology
Gene Expression
Humans
Membrane Proteins - physiology
Mice
Organ Specificity
Receptors, Fibroblast Growth Factor - chemistry
Receptors, Fibroblast Growth Factor - metabolism
Vertebrates: endocrinology
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Summary:Fibroblast growth factor 21 (FGF21) is a pleiotropic hormone-like protein and a major metabolic regulator. However, several key aspects of FGF21 biology remain poorly understood. Indeed, the list of controversies in the FGF21 field spans a variety of topics, from basic matters such as the anatomic distribution of FGF21 expression and the molecular composition of the FGF21 receptor, to the ultimate question of therapeutic relevance of FGF21-dependent pathways in humans. In this paper, we focus on current challenges in the field in an attempt to provide a balanced overview of FGF21 biology and guide future research into this exciting metabolic target.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2010.11.003