Expression of serum miR-221 in human hepatocellular carcinoma and its prognostic significance

► Serum miRNA expression was investigated in 46 HCC patients. ► Correlations between miR-221 expression and the clinical features were evaluated. ► miR-221 expression was correlated with tumor size, cirrhosis and tumor stage. ► Serum miR-221 can provide predictive significance for prognosis of HCC p...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical and biophysical research communications 2011-03, Vol.406 (1), p.70-73
Main Authors: Li, Jipeng, Wang, Yiping, Yu, Wanjun, Chen, Jun, Luo, Jianping
Format: Article
Language:English
Subjects:
Adult
Biomarkers, Tumor - blood
Biomarkers, Tumor - metabolism
Carcinoma, Hepatocellular - blood
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
Female
HCC
Humans
Liver Neoplasms - blood
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Male
microRNA
MicroRNAs - blood
MicroRNAs - metabolism
Middle Aged
Prognosis
Serum
Survival Analysis
Up-Regulation
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:► Serum miRNA expression was investigated in 46 HCC patients. ► Correlations between miR-221 expression and the clinical features were evaluated. ► miR-221 expression was correlated with tumor size, cirrhosis and tumor stage. ► Serum miR-221 can provide predictive significance for prognosis of HCC patients. To investigate whether the serum miR-221 expression correlates with clinicopathologic features and the prognosis of hepatocellular carcinoma (HCC) patients. Four miRNAs (miR-221, miR-222, miR-21 and miR-224) related to HCC were selected in the present study. Serum miRNA expression was investigated in 46 HCC patients and 20 healthy normal controls by using real-time PCR technique, and then correlations between miR-221 expression and the clinicopathological features and prognosis of HCC patients were evaluated. The four miRNAs were found to be differentially overexpressed in HCC serum samples, and high level of miR-221 expression was correlated with tumor size ( P < 0.001), cirrhosis ( P = 0.003) and tumor stage ( P = 0.016). In addition, Kaplan–Meier survival analysis showed that the overall survival rate of the high miR-221 expression group (27.6%) was significantly lower than that of the low miR-221 expression group (62.3%, P < 0.05). Serum miR-221, upregulated in HCC, can provide predictive significance for prognosis of HCC patients.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2011.01.111