Diffuse large B-cell lymphoma with concordant bone marrow involvement has peculiar genomic profile and poor clinical outcome

Bone marrow (BM) involvement in diffuse large B‐cell lymphoma (DLBCL) can be morphologically discordant from the primary tumor. Concordant BM infiltration has been shown associated with a poorer outcome in patients treated with CHOP. In order to evaluate tumor‐related factors leading to BM involveme...

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Published in:Hematological oncology 2011-03, Vol.29 (1), p.38-41
Main Authors: Chigrinova, Ekaterina, Mian, Michael, Scandurra, Marta, Greiner, Timothy C., Chan, Wing C., Vose, Julie M., Inghirami, Giorgio, Chiappella, Annalisa, Baldini, Luca, Ponzoni, Maurilio, Ferreri, Andrés J.M., Franceschetti, Silvia, Gaidano, Gianluca, Tucci, Alessandra, Facchetti, Fabio, Lazure, Thierry, Lambotte, Olivier, Montes-Moreno, Santiago, Piris, Miguel A., Nomdedeu, Josep Fr, Uccella, Silvia, Rancoita, Paola M.V., Kwee, Ivo, Zucca, Emanuele, Bertoni, Francesco
Format: Article
Language:English
Subjects:
B-cell lymphoma
Bone marrow
Bone Marrow - pathology
CGH
chromosome 7
Chromosome Aberrations
Data processing
Gene Expression Profiling
Genomes
genomics
Humans
lymphoma
Lymphoma, Large B-Cell, Diffuse - genetics
Lymphoma, Large B-Cell, Diffuse - mortality
Lymphoma, Large B-Cell, Diffuse - pathology
Metastases
microarray
Prognosis
R-CHOP
Tumors
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Summary:Bone marrow (BM) involvement in diffuse large B‐cell lymphoma (DLBCL) can be morphologically discordant from the primary tumor. Concordant BM infiltration has been shown associated with a poorer outcome in patients treated with CHOP. In order to evaluate tumor‐related factors leading to BM involvement in DLBCL, we performed an integrated analysis of i) genomic profiles obtained with a high‐density genome wide SNP‐based arrays ii) immunomorphological and iii) clinical data from 133 patients uniformly treated with R‐CHOP. BM infiltration was found in 27 of 133 (20%) cases; and it was concordant in 18/27 (67%) cases. Concordant infiltration, but not discordant, influenced negatively OS, PFS and DFS and was associated with higher serum LDH, lower CR and higher PD rates. No association with cell of origin was found between BM+ and BM‐ DLBCL. As compared with BM‐ cases, BM+ DLBCL showed absence of 7q gain. Copyright © 2010 John Wiley & Sons, Ltd.
ISSN:0278-0232
1099-1069
DOI:10.1002/hon.953