Brain Activation During Silent Word Generation Evaluated with Functional MRI

This is a study of word generation during functional MRI (fMRI). Eleven normal healthy subjects were instructed to generate words covertly, (i.e., silently) that began with particular letters. Images were acquired on a conventional 1.5T scanner at three contiguous axial planes encompassing language-...

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Bibliographic Details
Published in:Brain and language 1998-09, Vol.64 (2), p.231-256
Main Authors: Friedman, Lee, Kenny, John T., Wise, Alexandria L., Wu, Dee, Stuve, Traci A., Miller, David A., Jesberger, John A., Lewin, Jonathan S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anatomical correlates of behavior
Behavioral psychophysiology
Biological and medical sciences
Brain - anatomy & histology
Brain - physiology
Cognition - physiology
Female
Fundamental and applied biological sciences. Psychology
Humans
Magnetic Resonance Imaging
Male
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Speech - physiology
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Summary:This is a study of word generation during functional MRI (fMRI). Eleven normal healthy subjects were instructed to generate words covertly, (i.e., silently) that began with particular letters. Images were acquired on a conventional 1.5T scanner at three contiguous axial planes encompassing language-related areas of the temporal and frontal lobe. The data were analyzed at the level of a Talairach box, after individually fitting the proportional Talairach grid system to each slice. The main variable of interest was the number of activated pixels within a Talairach box. Boxes with a significant increase in the proportion of activated pixels were located in three regions of the left neocortex: (1) Brodmann areas 44 and 45 in the dorsolateral frontal cortex (Broca's area), (2) areas 21 and 37 in the temporal cortex, (3) and the striate/extrastriate cortex (areas 17 & 18). The results are discussed in terms of a cognitive model of word generation and are compared, in detail, with the results of prior relevant imaging studies.
ISSN:0093-934X
1090-2155
DOI:10.1006/brln.1998.1953