Predictive factors for long-term survival in patients with clinically significant portal hypertension following resection of hepatocellular carcinoma

Background: Hepatic resection for hepatocellular carcinoma (HCC) is not currently recommended for patients with clinically significant portal hypertension (PHT); however, recent studies have shown similar post‐operative outcomes between patients with and without clinically significant PHT. Aim: To c...

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Published in:Liver international 2011-04, Vol.31 (4), p.485-493
Main Authors: Choi, Gi H., Park, Jun Y., Hwang, Ho K., Kim, Dong H., Kang, Chang M., Choi, Jin S., Park, Young N., Kim, Do Y., Ahn, Sang H., Han, Kwang-Hyub, Chon, Chae Y., Lee, Woo J.
Format: Article
Language:English
Subjects:
Carcinoma, Hepatocellular - surgery
Forecasting - methods
hepatocellular carcinoma
Humans
Hypertension, Portal - complications
Hypertension, Portal - physiopathology
Liver Cirrhosis - physiopathology
Liver Neoplasms - surgery
long-term survival
Multivariate Analysis
portal hypertension
Postoperative Complications - etiology
Postoperative Complications - physiopathology
Prognosis
Prothrombin Time
Republic of Korea
surgical resection
Survival Analysis
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Summary:Background: Hepatic resection for hepatocellular carcinoma (HCC) is not currently recommended for patients with clinically significant portal hypertension (PHT); however, recent studies have shown similar post‐operative outcomes between patients with and without clinically significant PHT. Aim: To clarify the post‐operative prognostic relevance of clinically significant PHT in Child–Pugh A cirrhotic patients. Methods: A total of 100 Child–Pugh A cirrhotic patients who underwent curative resection of HCC were eligible for this analysis. Patients were divided into two groups: PHT group (n=47) and non‐PHT group (n=53). Results: Clinicopathological variables showed no significant differences except for prothrombine time. Liver‐related complications were significantly higher in the PHT group (P=0.015), and the 5‐year overall survival rate was significantly higher in the non‐PHT group (78.7 vs. 37.9%, P
ISSN:1478-3223
1478-3231
DOI:10.1111/j.1478-3231.2010.02436.x