Clinicopathologic features and genotyping of patients with chronic HBV infection in the Upper Egypt

The aim of this study was to determine the clinicopathologic features and Hepatitis B virus genotypes in HBV-infected patients in the Upper Egypt. Eighty-three HBsAg-positive patients (28 carriers, 14 with chronic hepatitis, 32 with liver cirrhosis and 9 with hepatocellular carcinoma) were enrolled....

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Bibliographic Details
Published in:Cellular immunology 2010, Vol.265 (2), p.97-104
Main Authors: Zaky, Saad, Farghaly, Ahlam Mohamed, Rashed, Hebat-Allah, Hassan, Hywida, Faouzy, Ehab, Makhlouf, Nahed, Hussein, Mahmoud Rezk Abdelwahed
Format: Article
Language:English
Subjects:
Adult
Age Factors
Alanine Transaminase - blood
Aspartate Aminotransferases - blood
Carcinoma, Hepatocellular - complications
Demography
Egypt
Female
Genome, Viral
Genotype D
HBV
Hepatitis B virus
Hepatitis B virus - genetics
Hepatitis B, Chronic - blood
Hepatitis B, Chronic - complications
Hepatitis B, Chronic - epidemiology
Hepatitis B, Chronic - physiopathology
Hepatitis B, Chronic - virology
Humans
Liver Cirrhosis - complications
Liver Neoplasms - complications
Male
Middle Aged
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Summary:The aim of this study was to determine the clinicopathologic features and Hepatitis B virus genotypes in HBV-infected patients in the Upper Egypt. Eighty-three HBsAg-positive patients (28 carriers, 14 with chronic hepatitis, 32 with liver cirrhosis and 9 with hepatocellular carcinoma) were enrolled. Blood was collected and serum samples obtained were screened for Hepatitis markers genotyping was conducted for 6 HBV genotypes (A through F) using a method for genotyping HBV by primer specific polymerase chain reaction. Genotype D was the only genotype detected in different clinical forms of chronic HBV infection (carriers, chronic hepatitis, cirrhosis and hepatocellular carcinoma) and, in all patients who had elevated or normal alanine aminotransferase levels and in all ages. HBeAg was absent in 78 patients suggesting the presence of pre-core or core mutations. Positive correlation was found among serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), histological activity index and grade of hepatitis. This study provides the first indication about the clinicopathologic features of HBV-infected patients in the Upper Egypt. It also reports the predominance of genotype D in this region.
ISSN:0008-8749
1090-2163
DOI:10.1016/j.cellimm.2010.07.008