Asymmetry of prefrontal cortex activities and catechol-O-methyltransferase Val158Met genotype in patients with panic disorder during a verbal fluency task: Near-infrared spectroscopy study

We examined the relationship between the catechol-O-methyltransferase (COMT) Val158Met genotype and frontal lobe function by using multi-channel near-infrared spectroscopy (NIRS). The present study investigated oxygenated ([oxy-Hb]) and deoxygenated ([deoxy-Hb]) hemoglobin concentration changes duri...

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Bibliographic Details
Published in:Neuroscience letters 2009-03, Vol.452 (1), p.63-67
Main Authors: Tanii, Hisashi, Nishimura, Yukika, Inoue, Ken, Koshimizu, Hiroyuki, Matsumoto, Ryusuke, Takami, Tetsuhei, Hara, Naomi, Nishida, Atsushi, Okada, Motohiro, Kaiya, Hisanobu, Okazaki, Yuji
Format: Article
Language:English
Subjects:
Adult
Anxiety
Autonomic dysfunction
Brain Mapping
Catechol O-Methyltransferase - genetics
Catechol-O-methyltransferase
Female
Functional Laterality - genetics
Genotype
Hemoglobins - metabolism
Humans
Male
Methionine - genetics
Middle Aged
Near-infrared spectroscopy
Neuropsychological Tests
Panic disorder
Panic Disorder - genetics
Panic Disorder - metabolism
Panic Disorder - pathology
Polymorphism, Genetic - genetics
Prefrontal Cortex - metabolism
Spectroscopy, Near-Infrared - methods
Valine - genetics
Verbal Behavior - physiology
Verbal fluency task
Young Adult
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Summary:We examined the relationship between the catechol-O-methyltransferase (COMT) Val158Met genotype and frontal lobe function by using multi-channel near-infrared spectroscopy (NIRS). The present study investigated oxygenated ([oxy-Hb]) and deoxygenated ([deoxy-Hb]) hemoglobin concentration changes during the performance of a verbal fluency task in the frontal region of 71 patients with panic disorder (PD). The activation of [oxy-Hb] on the right lateral prefrontal cortex was observed in the Met/Met genotype of the COMT gene polymorphism of PD patient groups in the analysis of NIRS, which seems to be related to the autonomic dysfunction in the pathogenesis of PD.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2009.01.044