Paradoxical contractile properties in the knee extensors of HIV-infected men treated with antiretroviral therapy

We assessed contractile properties in the knee extensors of 18 men with the human immunodeficiency virus (HIV+) being treated with antiretroviral therapy (ART), and 9 healthy controls matched for age and body mass index. We found significant, divergent differences between groups with regard to force...

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Bibliographic Details
Published in:Applied physiology, nutrition, and metabolism nutrition, and metabolism, 2010-10, Vol.35 (5), p.713-717
Main Authors: Russ, David W, Scott, Wayne B, Oursler, Krisann K, King, Jenna Salter
Format: Article
Language:English
Subjects:
acquired immunodeficiency syndrome
activation centrale
AIDS
Anti-HIV Agents - therapeutic use
Antiretroviral drugs
antiretroviral therapy
Antiviral agents
Biological and medical sciences
Body mass
Body mass index
Calcium (mitochondrial)
Calcium - metabolism
central activation
Contractility
Drug therapy
force relaxation
Fundamental and applied biological sciences. Psychology
Health
Health aspects
HIV
HIV infection
HIV Infections - drug therapy
HIV Infections - physiopathology
Human immunodeficiency virus
Humans
Knee
Knee Joint - physiology
Knees
Male
Men
Middle Aged
Mitochondria
Mitochondria - physiology
Muscle Contraction - physiology
muscle squelettique
Muscle, Skeletal - physiology
Muscles
Muscular system
Nutrition
Physiological aspects
Relaxation
relâchement de la tension
skeletal muscle
Studies
syndrome d'immunodéficience acquise
Therapy
Torque
Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
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Summary:We assessed contractile properties in the knee extensors of 18 men with the human immunodeficiency virus (HIV+) being treated with antiretroviral therapy (ART), and 9 healthy controls matched for age and body mass index. We found significant, divergent differences between groups with regard to force relaxation. Half-times of twitch relaxation were shorter (62.6 ± 5.4 ms vs. 48.9 ± 3.0 ms;; p = 0.045) and maximum rates of torque relaxation were slower (0.47% ± 0.04%·s -1 vs. 1.32% ± 0.10%·s -1 ;; p < 0.001) in HIV+ individuals. These preliminary findings suggest potential intramuscular impairments in HIV+ individuals on ART, perhaps because of interactions between calcium handling and mitochondrial dysfunction.
ISSN:1715-5312
1715-5320
DOI:10.1139/H10-049