Interleukin-6 promoter polymorphism −174 G/C is associated with nephritis in Portuguese Caucasian systemic lupus erythematosus patients

Interleukin-6 (IL-6) is a multifunctional cytokine with an important pathophysiological role in systemic lupus erythematosus (SLE). The polymorphism of the IL-6 gene promoter at position −174, which appears to influence the production of this cytokine, has been associated with susceptibility to some...

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Bibliographic Details
Published in:Clinical rheumatology 2011-03, Vol.30 (3), p.409-413
Main Authors: Santos, Maria José, Fernandes, Diana, Capela, Susana, da Silva, Jose Canas, Fonseca, João Eurico
Format: Article
Language:English
Subjects:
Age of Onset
Brief Report
European Continental Ancestry Group
Female
Humans
interleukin-6
Interleukin-6 - genetics
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - genetics
Lupus Erythematosus, Systemic - immunology
Male
Medicine
Medicine & Public Health
Nephritis - complications
Nephritis - genetics
Polymorphism, Genetic
Portugal
Portuguese Caucasian
Promoter Regions, Genetic
Rheumatology
Systemic lupus erythematosus
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Summary:Interleukin-6 (IL-6) is a multifunctional cytokine with an important pathophysiological role in systemic lupus erythematosus (SLE). The polymorphism of the IL-6 gene promoter at position −174, which appears to influence the production of this cytokine, has been associated with susceptibility to some rheumatic diseases. The aim of this study is to investigate whether the IL-6 −174 G/C polymorphism associates with lupus susceptibility or affects disease characteristics in Portuguese patients with SLE. The association between −174 G/C and lupus diagnosis was studied in 115 adult SLE patients (95.7% females) and 152 healthy controls (94.7% females), all Caucasians. There were no significant differences in genotype or allele frequency between patients and controls. The −174 C/C genotype was independently associated with renal disease and the C allele with the presence of irreversible damage. The IL-6 gene promoter polymorphism at position −174 does not contribute to SLE susceptibility in Portuguese Caucasian patients but may predispose to specific manifestations of the disease.
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-010-1640-y