Using metabolomic analysis to understand inflammatory bowel diseases

Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD) attributed to a dysregulated immune response towards intestinal microbiota. Although various susceptibility genes have been identified for CD and UC, the exact disease etiology is unclear and complicated by t...

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Bibliographic Details
Published in:Inflammatory bowel diseases 2011-04, Vol.17 (4), p.1021-1029
Main Authors: Lin, Hui‐Ming, Helsby, Nuala A., Rowan, Daryl D., Ferguson, Lynnette R.
Format: Article
Language:English
Subjects:
Crohn's disease
Environmental factors
Etiology
Humans
Immune response
Inflammatory bowel diseases
Inflammatory Bowel Diseases - diagnosis
Inflammatory Bowel Diseases - metabolism
Inflammatory Bowel Diseases - therapy
Intestinal microflora
Intestine
metabolite profiling
Metabolites
metabolomic
Metabolomics
metabonomic
Ulcerative colitis
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Description
Summary:Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD) attributed to a dysregulated immune response towards intestinal microbiota. Although various susceptibility genes have been identified for CD and UC, the exact disease etiology is unclear and complicated by the influence of environmental factors. Metabolomic analysis enables high sample throughput measurements of multiple metabolites in biological samples. The use of metabolomic analysis in medical sciences has revealed metabolite perturbations associated with diseases. This article provides a summary of the current understanding of IBD, and describes potential applications and previous metabolomic analysis in IBD research to understand IBD pathogenesis and improve IBD therapy. Inflamm Bowel Dis 2011
ISSN:1078-0998
1536-4844
1536-4844
DOI:10.1002/ibd.21426