Characterization of H9N2 influenza viruses isolated from Dongting Lake wetland in 2007

In 2007, a total of eight H9N2 influenza viruses were isolated from the water and fowl feces in Dongting Lake wetland, China. The genomes of the eight viruses were sequenced, and all eight gene segments were subjected to phylogenetic analysis. The results showed that all the isolates belonged to the...

Full description

Saved in:
Bibliographic Details
Published in:Archives of virology 2011, Vol.156 (1), p.95-105
Main Authors: Zhang, Hongbo, Xu, Bing, Chen, Quanjiao, Chen, Ze
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Animals
Anseriformes
Avian flu
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Bird migration
Eggs
Evolution & development
Feces
Feces - virology
Fundamental and applied biological sciences. Psychology
Genome, Viral
Infectious Diseases
Influenza A Virus, H9N2 Subtype - classification
Influenza A Virus, H9N2 Subtype - genetics
Influenza A Virus, H9N2 Subtype - isolation & purification
Lung - virology
Medical Microbiology
Mice
Microbiology
Miscellaneous
Original Article
Phylogeny
Poultry
Virology
Virus Replication
Viruses
Water Microbiology
Wetlands
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In 2007, a total of eight H9N2 influenza viruses were isolated from the water and fowl feces in Dongting Lake wetland, China. The genomes of the eight viruses were sequenced, and all eight gene segments were subjected to phylogenetic analysis. The results showed that all the isolates belonged to the same genotype, in which the HA, NA and NS gene segments were Chicken/Beijing/94-like; the PB2, PB1, PA and NP gene segments were Chicken/Shanghai/F/98-like; and the M gene was Quail/Hong Kong/G1/97-like. Animal experiments showed low pathogenicity of the selected viruses for chickens, although some chickens died after inoculation. The viruses showed no overt clinical signs in mice, but they could replicate in murine lungs prior to adaptation.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-010-0836-4