Building-Associated Neurological Damage Modeled in Human Cells: A Mechanism of Neurotoxic Effects by Exposure to Mycotoxins in the Indoor Environment

Damage to human neurological system cells resulting from exposure to mycotoxins confirms a previously controversial public health threat for occupants of water-damaged buildings. Leading scientific organizations disagree about the ability of inhaled mycotoxins in the indoor environment to cause adve...

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Bibliographic Details
Published in:Mycopathologia (1975) 2010-12, Vol.170 (6), p.377-390
Main Authors: Karunasena, Enusha, Larrañaga, Michael D, Simoni, Jan S, Douglas, David R, Straus, David C
Format: Article
Language:English
Subjects:
Air pollution
Air quality
Apoptosis
Astrocytes
Astrocytes - drug effects
Biomedical and Life Sciences
Brain
Buildings
Cells
Cells, Cultured
Construction
Endothelial cells
Endothelial Cells - drug effects
Eukaryotic Microbiology
Fungi
Health sciences
Humans
Indoor-air quality
Industrialized nations
Inflammation
Life Sciences
Medical Microbiology
Metabolites
Microbial Ecology
Microbiology
Mycotoxins
Nervous system
Neural stem cells
Neural Stem Cells - drug effects
Neurological damage
Neurotoxicity
Outdoor air quality
Physiology
Plant Sciences
Public health
Satratoxin
Sick-building syndrome
Stachybotrys chartarum
Stress, Physiological
trichothecenes
Trichothecenes - toxicity
Water damage
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Summary:Damage to human neurological system cells resulting from exposure to mycotoxins confirms a previously controversial public health threat for occupants of water-damaged buildings. Leading scientific organizations disagree about the ability of inhaled mycotoxins in the indoor environment to cause adverse human health effects. Damage to the neurological system can result from exposure to trichothecene mycotoxins in the indoor environment. This study demonstrates that neurological system cell damage can occur from satratoxin H exposure to neurological cells at exposure levels that can be found in water-damaged buildings contaminated with fungal growth. The constant activation of inflammatory and apoptotic pathways at low levels of exposure in human brain capillary endothelial cells, astrocytes, and neural progenitor cells may amplify devastation to neurological tissues and lead to neurological system cell damage from indirect events triggered by the presence of trichothecenes.
ISSN:0301-486X
1573-0832
DOI:10.1007/s11046-010-9330-5