Aspects of gene polymorphisms in cerebral infarction: inflammatory cytokines

During the last decade, a growing corpus of evidence has indicated an important role of inflammatory cytokines in the pathogenesis of cerebral lesion following stroke. Recent data suggest that genetics may in turn contribute to modulating the effects of inflammatory cytokines on cerebral infarction...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2005-04, Vol.62 (7-8), p.824-833
Main Authors: Um, J-Y, Jeong, H-J, Park, R-K, Hong, S-H, Kim, H M
Format: Article
Language:English
Subjects:
Animals
Cell Adhesion Molecules - genetics
Cell Adhesion Molecules - immunology
Cerebral infarction
Cerebral Infarction - etiology
Cerebral Infarction - genetics
Cerebral Infarction - immunology
Cytokines
Cytokines - genetics
Cytokines - immunology
Genetics
Humans
Pathology
Polymorphism
Polymorphism, Genetic
Stroke
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Summary:During the last decade, a growing corpus of evidence has indicated an important role of inflammatory cytokines in the pathogenesis of cerebral lesion following stroke. Recent data suggest that genetics may in turn contribute to modulating the effects of inflammatory cytokines on cerebral infarction (CI). This paper reviews the physiologic characteristics of major inflammatory cytokines and recent research developments related to cell biology and pathobiology in CI. In particular, this review focuses on the genetic aspects of inflammatory cytokines and their implications in CI.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-004-4267-9