Expression of slow skeletal myosin binding C-protein in normal adult mammalian heart

Myosin binding C-protein exists in three main isoforms in striated muscle. While expression of cardiac muscle type C-protein is detected in skeletal muscle during early fetal development, there have not so far been any reports of the expression of the skeletal muscle isoforms of this protein in eith...

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Bibliographic Details
Published in:Journal of muscle research and cell motility 2005-04, Vol.26 (2-3), p.143-148
Main Authors: Dhoot, Gurtej K, Perry, Samuel V
Format: Article
Language:English
Subjects:
Adult
Animals
Blotting, Western
Carrier Proteins - metabolism
Cattle
Gene Expression
Heart - physiology
Heart Atria - metabolism
Heart Septum - metabolism
Heart Ventricles - metabolism
Humans
Immunohistochemistry
In Vitro Techniques
Muscular system
Myocardium - metabolism
Myosins - metabolism
Proteins
Rabbits
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Summary:Myosin binding C-protein exists in three main isoforms in striated muscle. While expression of cardiac muscle type C-protein is detected in skeletal muscle during early fetal development, there have not so far been any reports of the expression of the skeletal muscle isoforms of this protein in either developing or adult vertebrate heart. The present study demonstrates slow skeletal muscle type C-protein in moderate amount in right atrium and interatrial septum of adult human, rabbit, rat and bovine hearts using both immunocytochemical and immunoblotting procedures.
ISSN:0142-4319
1573-2657
DOI:10.1007/s10974-005-3089-1